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The Road to Discovery
  • Language: en

The Road to Discovery

  • Type: Book
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  • Published: 2016
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  • Publisher: Unknown

The Road to Discovery: A Short History of Cold Spring Harbor Laboratory was published in 2015 to mark the 125th anniversary of Cold Spring Harbor Laboratory. At Cold Spring Harbor, in a bucolic setting on the north shore of New York's Long Island, two interdependent research centers in biology were founded as Charles Darwin's insights into heredity and evolution shook the world of science. Fifty years later, those centers would emerge as a single institution that would cradle another revolution, the new science of molecular biology, and advance to world renown in research and professional education. It is a remarkable story, with a path of progress that was neither simple nor assured. The Ro...

Lab Ref
  • Language: en
  • Pages: 259

Lab Ref

  • Type: Book
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  • Published: 2002
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  • Publisher: CSHL Press

"The first Lab Ref volume compiled recipes and reference data drawn from a selection of our manuals and was intended to save time and spare frustration." ... "In the same spirit, Lab Ref 2 again assembles in one place a new selection of reference information that should maximize the volume's value in a crowded laboratory environment."--Note.

Phage Display
  • Language: en
  • Pages: 724

Phage Display

  • Type: Book
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  • Published: 2001
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  • Publisher: CSHL Press

Phage-display technology has begun to make critical contributions to the study of molecular recognition. DNA sequences are cloned into phage, which then present on their surface the proteins encoded by the DNA. Individual phage are rescued through interaction of the displayed protein with a ligand, and the specific phage is amplified by infection of bacteria. Phage-display technology is powerful but challenging and the aim of this manual is to provide comprehensive instruction in its theoretical and applied so that any scientist with even modest molecular biology experience can effectively employ it. The manual reflects nearly a decade of experience with students of greatly varying technical expertise andexperience who attended a course on the technology at Cold Spring Harbor Laboratory. Phage-display technology is growing in importance and power. This manual is an unrivalled source of expertise in its execution and application.

Lab Dynamics
  • Language: en
  • Pages: 184

Lab Dynamics

  • Type: Book
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  • Published: 2005
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  • Publisher: CSHL Press

"Lab Dynamics is a book about the challenges to doing science and dealing with the individuals involved, including oneself. The authors, a scientist and a psychotherapist, draw on principles of group and behavioral psychology but speak to scientists in their own language about their own experiences. They offer in-depth, practical advice, real-life examples, and exercises tailored to scientific and technical workplaces on topics as diverse as conflict resolution, negotiation, dealing with supervision, working with competing peers, and making the transition from academia to industry." "This is a uniquely valuable contribution to the scientific literature, on a subject of direct importance to lab heads, postdocs, and students. It is also required reading for senior staff concerned about improving efficiency and effectiveness in academic and industrial research."--BOOK JACKET

The PTEN Family
  • Language: en

The PTEN Family

  • Type: Book
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  • Published: 2019
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  • Publisher: Unknown

"PTEN is an important cellular enzyme that is frequently mutated in cancer. In normal cells, it downregulates signaling through the PI3-kinase pathway that controls cell proliferation. When PTEN is mutated, the PI3 pathway becomes overactive, which can contribute to cancer. This volume examines advances in our understanding of the functions of the PTEN protein, its regulation, and how loss of PTEN can promote the development and progression of different cancers"--

Essentials of Glycobiology
  • Language: en
  • Pages: 702

Essentials of Glycobiology

  • Type: Book
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  • Published: 1999
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  • Publisher: CSHL Press

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

The Molecular Gaze
  • Language: en
  • Pages: 272

The Molecular Gaze

  • Type: Book
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  • Published: 2004
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  • Publisher: CSHL Press

And they suggest the ways in which DNA representations relate to archetypal images that have appeared throughout the history of art."--BOOK JACKET.

Telomeres
  • Language: en
  • Pages: 598

Telomeres

  • Type: Book
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  • Published: 2006
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  • Publisher: Unknown

An up-to-date survey of the current exciting state of telomere biology. Telomeres – specialized structures found at the ends of chromosomes – are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

Translation Mechanisms and Control
  • Language: en
  • Pages: 499

Translation Mechanisms and Control

  • Type: Book
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  • Published: 2018-09-30
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  • Publisher: Unknown

A subject collection from Cold Spring Harbor Perspectives in Biology.

Restriction Enzymes
  • Language: en
  • Pages: 346

Restriction Enzymes

  • Type: Book
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  • Published: 2019
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  • Publisher: Unknown

Restriction enzymes cleave DNA at specific recognition sites and have many uses in molecular biology, genetics, and biotechnology. More than 4000 restriction enzymes are known today, of which more than 621 are commercially available, justifying their description by Nobel Prize winner Richard Roberts as "the workhorses of molecular biology." This book by Wil Loenen is the first full-length history of these invaluable tools, from their recognition in the 1950s to the flowering of their development in the 1970s and 1980s to their ubiquitous availability today. Loenen has worked with restriction enzymes throughout her career as a research scientist, during which she came to know many of the lead...