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Rock Deformation from Field, Experiments and Theory
Ernie Rutter has made, and continues to make, a significant impact in the field of rock deformation. He has studied brittle and plastic deformation processes that occur within both the oceanic and continental crust, as well as other key properties such as the permeability and seismic velocities of these rocks. His approach has been one that integrates field observations, laboratory experiments and theoretical analyses. This volume celebrates Ernie's key contribution to rock deformation and structural geology by bringing together a collection of papers that represent this broad approach. The papers within the volume address key issues that remain within these fields. These range from fundamental studies of brittle and plastic behaviour along with the resultant structures and microstructures from both the field and laboratory, to applied problems where a better understanding of the deformation and properties of the crust is still needed.
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Frontiers Of Reliability
This volume presents recent results in reliability theory by leading experts in the world. It will prove valuable for researchers, and users of reliability theory. It consists of refereed invited papers on a broad spectrum of topics in reliability. The subjects covered include Bayesian reliability, Bayesian reliability modeling, confounding in a series system, DF tests, Edgeworth approximation to reliability, estimation under random censoring, fault tree reduction for reliability, inference about changes in hazard rates, information theory and reliability, mixture experiment, mixture of Weibull distributions, queuing network approach in reliability theory, reliability estimation, reliability modeling, repairable systems, residual life function, software spare allocation systems, stochastic comparisons, stress-strength models, system-based component test plans, and TTT-transform.
Thyroid and Heart
In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies – including multicenter studies – have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely. This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, struct...
Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology
MicroRNAs (miRNAs) are small noncoding RNAs that are 19–24 nucleotides in length, following maturation. Recent evidence has demonstrated their key role as post-transcriptional regulators of gene expression through the binding of specific sequences within target messenger RNA (mRNA). miRNAs are involved in the synthesis of a very large number of proteins, and it is speculated that they could regulate up to 30% of the human genome. They control virtually every cellular process and are essential for animal development, cell differentiation, and homeostasis. Altered miRNA expression has been linked to such pathological events as inflammatory, degenerative, or autoimmune processes and have been...
The Anticancer Drugs
This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer. The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. Drawing on the fields of authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine, this timely book is extensively referenced and provides a historical background for the development of each class of drugs.
Exploring the Realms of Nature for Nanosynthesis
Nature, by dint of its constitution, harbors many unassuming mysteries broadly manifested by its constituent cohorts. If physics is the pivot that holds nature and chemistry provides reasons for its existence, then the rest is just manifestation. Nanoscience and technology harbor the congruence of these two core subjects, whereby many phenomenon may be studied in the same perspective. That nature operates at nanoscale—obeying the principles of thermodynamics and supramolecular chemistry—is a well understood fact manifested in a variety of life processes: bones are restored after a fracture; clots potentially leading to cerebral strokes can be dissolved. The regeneration of new structures...
Developmental State and the Dalit Question in Madhya Pradesh: Congress Response
Dalit assertion has been a central feature of the states in the Hindi heartland since the mid-1980s, leading to the rise of political consciousness and identity-based lower-caste parties. The present study focuses on the different political response of the Congress party to identity assertion in Madhya Pradesh under the leadership of Digvijay Singh. In Uttar Pradesh and Bihar, in response to the strong wave of Dalit assertion that swept the region, parties such as the Bahujan Samaj Party (BSP) and the Rashtriya Janata Dal (RJD) used strategies of political mobilisation to consolidate Dalit/backward votes and capture state power. In Madhya Pradesh, in contrast, the Congress party and Digvijay...
