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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. - Basic Principles, Specialized Uses, and Genetic Applications - LCM and its application in genomics and proteomics - Fluorescence in situ hybridization of LCM isolated nuclei from paraffin sections - Noncontact laser catapulting for the functional genomics and proteomics - Use of LCM for clonal analysis, in carcinoma analysis, to assess development, in complex tissue, in pathology, gene discovery, and more
Reviews recent and emerging clinical laboratory tests that can help in the early detection, evaluation, and prediction of human tumors. Emphasizing the importance of molecular and genetic RNA/DNA tets that detect persons at high risk for specific cancers, the authors explore these novel serological assays, cellular assays useful for anatomic pathology, and molecular and genetic assays.
Intraoperative radiotherapy (IORT) is a treatment delivery technique with reports starting in the early 20th century. There are numerous advantages of IORT in oncology including delivery of a tumoricidal radiation dose in a single treatment, direct visualization of the treatment area of interest, decreasing dose to surrounding tissues, among others. In this series we focus on the clinical application, radiobiology and physics of IORT with an emphasis on the Intrabeam system. As medicine and health care continue to evolve the new frontier of personalized medicine must continue to rigorously evaluate and implement technologies that limit costs and provide meaningful therapeutic benefit.
This book is Concise, portable, and user-friendly. “Sentinel Node Biopsy in Breast Cancer” focuses on the background, evolution, and newer advances in the concepts and techniques of sentinel node biopsy in patients with breast cancer. The authors include global experts in the field from India, the UK, the USA, and other countries to cover up the regional differences and biases and provide clear and evidence-based answers to all aspects focusing on the address of the axilla in breast cancer which is now arguably the most common cancer of the human race. Key features: A detailed and practical approach to the surgical anatomy of axilla An up-to-date review of all landmark trials in the field of sentinel node biopsy This book provides concise guidelines and the algorithmic & step by step approach to various techniques, including recent advances. Explains about limitations and merits of all sentinel node biopsy techniques in breast cancer and the approach to tailoring it to the patient, center, and surgeon. Address of axilla in various resource-constrained scenarios.
Ultrasound Elastography for Biomedical Applications and Medicine Ivan Z. Nenadic, Matthew W. Urban, James F. Greenleaf, Mayo Clinic Ultrasound Research Laboratory, Mayo Clinic College of Medicine, USA Jean-Luc Gennisson, Miguel Bernal, Mickael Tanter, Institut Langevin – Ondes et Images, ESPCI ParisTech CNRS, France Covers all major developments and techniques of Ultrasound Elastography and biomedical applications The field of ultrasound elastography has developed various techniques with the potential to diagnose and track the progression of diseases such as breast and thyroid cancer, liver and kidney fibrosis, congestive heart failure, and atherosclerosis. Having emerged in the last decad...
Numerous questions remain regarding the origin, release, clearance, clinical utility, and possible functionality of circulating nucleic acids. Serum proteomics is introduced as a new topic to CNAPS and is expected to provide yet another platform for breakthrough discoveries. Serum proteomics topics will address both cancer and early pregnancy.
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Europe on Trial explores the history of collaboration, retribution, and resistance during World War II. These three themes are examined through the experiences of people and countries under German occupation, as well as Soviet, Italian, and other military rule. Those under foreign rule faced innumerable moral and ethical dilemmas, including the question of whether to cooperate with their occupiers, try to survive the war without any political involvement, or risk their lives by becoming resisters. Many chose all three, depending on wartime conditions. Following the brutal war, the author discusses the purges of real or alleged war criminals and collaborators, through various acts of violence, deportations, and judicial proceedings at the Nuremberg International Military Tribunal as well as in thousands of local courts. Europe on Trial helps us to understand the many moral consequences both during and immediately following World War II.