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Chemical Mixtures and Combined Chemical and Nonchemical Stressors
In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments. Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.
Phthalates and Cumulative Risk Assessment
People are exposed to a variety of chemicals throughout their daily lives. To protect public health, regulators use risk assessments to examine the effects of chemical exposures. This book provides guidance for assessing the risk of phthalates, chemicals found in many consumer products that have been shown to affect the development of the male reproductive system of laboratory animals. Because people are exposed to multiple phthalates and other chemicals that affect male reproductive development, a cumulative risk assessment should be conducted that evaluates the combined effects of exposure to all these chemicals. The book suggests an approach for cumulative risk assessment that can serve as a model for evaluating the health risks of other types of chemicals.
Dietary and Nutritional Indices and Chronic Diseases
Chronic diseases such as diabetes, cardiovascular diseases, and cancers are known as a substantive worldwide challenge for health systems and are major contributors to mortality and morbidity. According to the World Health Organization, 71% of all deaths and 63.8 % of Disability-Adjusted Life Years (DALYs) are attributed to chronic diseases. The composition of a diet influences health status and affects the occurrence and severity of chronic diseases. As different components of a diet correlate and interact with one another, addressing only individual dietary constituents does not usually help in analyzing the extent to which diets may prevent or contribute to the development or progress of ...
Handbook of Computational Statistics
The Handbook of Computational Statistics - Concepts and Methods (second edition) is a revision of the first edition published in 2004, and contains additional comments and updated information on the existing chapters, as well as three new chapters addressing recent work in the field of computational statistics. This new edition is divided into 4 parts in the same way as the first edition. It begins with "How Computational Statistics became the backbone of modern data science" (Ch.1): an overview of the field of Computational Statistics, how it emerged as a separate discipline, and how its own development mirrored that of hardware and software, including a discussion of current active researc...
Biomarkers of Toxic Metals
The current exposure of human populations to toxic metals makes the prevention and control of such exposures crucial. Biomarkers are undoubtably recognized as vital tools to achieve these goals. This book is for researchers, toxicologists, physicians, pharmacologists and those working in governmental regulatory agencies and other public health fields. The first part of this book covers general aspects of biomarkers of toxic metals, while parts 2 and 3 cover biomarkers of xenobiotic metals and essential metals with potential for toxicity, respectively. In part 4, novel approaches to metal biomarkers are focused.
Fundamentals of Ecotoxicology
An integrated analysis exploring current and relevant concepts, Fundamentals of Ecotoxicology: The Science of Pollution, Fourth Edition extends the dialogue further from the previous editions and beyond conventional ecosystems. It explores landscape, regional, and biospheric topics, communicating core concepts with subjects ranging from molecular to global issues. It addresses the increasing growth and complexity of ecotoxicological problems, contains additional vignettes, and employs input from a variety of experts in the field. Divided into 14 chapters, the book begins with an overall history of the field. It details the essential features of the key contaminants of concern today, includin...
Environmental Impacts on Women’s Health Disparities and Reproductive Health: Advancing environmental health equity in clinical and public health practice
On April 27-28, 2022, the National Institute of Environmental Health Sciences (NIEHS) hosted a workshop to examine the effects of chemical and non-chemical stressors on maternal and fetal adverse health outcomes, discuss diseases specific to women and individuals assigned female at birth, and to assess the role of racial and ethnic disparities in environmental exposures. The concepts of early and lifetime exposures and the correlation between socioeconomic status, hazardous exposures, and communities of color were explored with a focus on the synergistic impacts on women’s health. Current research and knowledge gaps in the context of environmental exposures and women’s reproductive health disparities were examined. This Research Topic reflects the work presented at the NIEHS 2-day workshop or work suggesting critical ways to advance environmental health disparities and women’s reproductive health research, or environmental health equity in public health and clinical practice.
Quantitative Ecotoxicology, Second Edition
Quantitative Ecotoxicology, Second Edition explores models and methods of quantitative ecotoxicology at progressively higher biological scales using worked examples and common software packages. It complements the author’s previous books, Fundamentals of Ecotoxicology, Third Edition and Ecotoxicology: A Comprehensive Treatment. Encouraging a more rigorous inferential approach to research, the book examines the quantitative features of the science of ecotoxicology. The first chapters lay the foundation by introducing fundamental concepts and definitions. The author traces the historical perspective, rationale, and characteristics of scientific ecotoxicology as well as the general measuremen...
Sex, Gender, and Epigenetics
Sex, Gender, and Epigenetics: From Molecule to Bedside explores our expanding knowledge of the science of epigenetics in which gene expression is modified as a consequence of small chemical additions to various components of the genome. The book provides an overview of the field, describing the epigenetic phenomena that unite biological sex and environmental experience to create the unique phenome of each individual. The book also analyzes the impact of ancestors' environmental experience on subsequent generations through the sex-specific transmission of environmentally induced epigenetic modifications. Here, international leaders in the field discuss both sex-specific normal physiology and ...
