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Swift, the Book, and the Irish Financial Revolution
Winner, 2010 Donald Murphy Prize for a Distinguished First Book, American Conference on Irish Studies Renowned as one of the most brilliant satirists ever, Jonathan Swift has long fascinated Hibernophiles beyond the shores of the Emerald Isle. Sean Moore's examination of Swift's writings and the economics behind the distribution of his work elucidates the humorist's crucial role in developing a renewed sense of nationalism among the Irish during the eighteenth century. Taking Swift's Irish satires, such as A Modest Proposal and the Drapier's Letters, as examples of anticolonial discourse, Moore unpacks the author's carefully considered published words and his deliberate drive to liberate the...
Ethanol, Its Active Metabolites, and Their Mechanisms of Action: Neurophysiological and Behavioral Effects
Ethanol, the main psychopharmacologically active ingredient of alcoholic drinks, represents a paradigmatic example of a research subject intrinsically able to perpetually self-generate interdisciplinary cutting-edge investigations. This eBook was inspired by the aim of providing an up-to-date characterization of the diverse effects of ethanol, of the possible mechanisms of action on different intracellular systems as well as of the hypothesized actions of ethanol and/or its metabolites on various neurotransmitters and neuromodulators. Indeed, the eBook provides a factual example of an excellent synthesis on the complex relationship between ethanol and its main biologically active metabolites...
Neuroactive metabolites of ethanol: a behavioral and neurochemical synopsis
Ethanol is a very elusive drug, which has mechanisms of action that are diverse and relatively non-selective. Moreover, ethanol has been demonstrated to be a biologically active substance by itself, but also a pro-drug of the neuroactive metabolites, acetaldehyde and acetate. Acetaldehyde has traditionally been known as a toxic substance with several effects on multiple systems. However, in the last few decades evidence has accumulated to reveal the specific and, in some instances, distinct neural actions of acetaldehyde and acetate that are in part responsible for some of the observed psychoactive effects of ethanol. The present issue will address these challenges to provide an up-to-date s...
The Impact of Active and Passive Smoking Upon Health and Neurocognitive Function
Tobacco smoking is a major risk factor for a number of chronic diseases, including a variety of cancers, lung disease and damage to the cardiovascular system. The World Health Organization recently calculated that there were 6 million smoking-attributable deaths per year and that this number is due to rise to about eight million per year by the end of 2030. Recent work has demonstrated that habitual smoking in adults is not only associated with a range of health problems, but may also contribute to a number of neurocognitive deficits, including deficits in memory and attention. One area of growing concern is the health and neurocognitive consequences of exposure to second-hand smoke or “pa...
