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Neurobiology of Psychiatric Disorders
This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the...
Perinatal Psychiatry
This book presents a comprehensive and multidisciplinary review of the field of perinatal psychiatry, bringing together the leading researchers to honor the original work of Dr Channi Kumar.
Prevention in Mental Health
The book brings together into a single text the interrelated but different research efforts to translate the current evidence on risk and outcome of severe mental disorders into a preventive perspective. The book also introduces a holistic approach to prevention in mental health, by combining biological, psychological and environmental evidence that attempts to blunt the risk and reduce the number of individuals with mental health vulnerabilities who eventually progress to the manifestation of a severe mental disorder. Finally, the book wants also to highlight the possibility to overcome the single disorder-oriented preventive approach in an attempt to intercept a wider at-risk youth populat...
Childhood Trauma in Mental Disorders
This volume presents a comprehensive overview of childhood trauma, considering the psychopathological definition and its neurobiological implications as well as its impact on different psychiatric disorders. The focus on childhood trauma rather than that occurring in adulthood is important due to its general “neuro-psyco-socio” and its specific biological implications, since trauma during childhood impacts directly on neurodevelopment. It has been suggested that early life stress increases vulnerability to psychiatric disorders; however, the exact mechanisms of this association are not yet completely understood. Although childhood trauma could be considered too unspecific to be an important risk factor for individual psychiatric disorders since it seems to occur across the board, it impacts differently on different psychiatric disorders, and it can modulate their clinical expression. Therefore, the assessment of early trauma needs to be included in the clinical evaluation of patients with psychiatric disorders. The volume will be an invaluable tool for psychiatrists, helping them to select suitable pharmacological, psychotherapeutic and rehabilitative treatments.
Behavioral Neurobiology of Depression and Its Treatment
The book highlights important new research using current state-of-the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in the neurobiological understanding of depression to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of depression research.
Consciousness and Cognition
What were the circumstances that led to the development of our cognitive abilities from a primitive hominid to an essentially modern human? The answer to this question is of profound importance to understanding our present nature. Since the steep path of our cognitive development is the attribute that most distinguishes humans from other mammals, this is also a quest to determine human origins. This collection of outstanding scientific problems and the revelation of the many ways they can be addressed indicates the scope of the field to be explored and reveals some avenues along which research is advancing. Distinguished scientists and researchers who have advanced the discussion of the mind...
The Maudsley Prescribing Guidelines in Psychiatry
The essential reference for anyone responsible for prescribing drugs for patients with mental health disorders. Widely and regularly used: the place to check for all relevant information on which drugs to prescribe, which side effects to look out for, how best to augment or switch drugs, such as antipsychotics, antidepressants, and anxiolytics. The book provides brief but detailed reviews of psychiatric disorders and relevant psychopharmacology, with general guidance based on the data reviewed and current clinical practice. Sections cover plasma monitoring, schizophrenia, bipolar disorder, depression, anxiety, children and adolescents, substance abuse and special patient groups. Each section has a full reference list so that the evidence base can be checked quickly, if required. The book covers prescribing drugs outside their licensed indications and their interaction with substances such as alcohol, nicotine and caffeine. Trainees will gain important information regarding the rational, safe and effective use of medications for patients with mental illness. Experienced clinicians will find excellent guidance regarding more complex issues that they may not encounter regularly.
Immunopsychiatry
This book assembles and presents the available data on the immune/inflammatory dysfunction in psychiatric disorders, indicating the potential of immune mechanisms as either biomarkers or therapeutic targets, as well as discussing the challenges ahead of incorporating this knowledge into clinical practice.
Perinatal Inflammation and Adult Psychopathology
Perinatal psychiatry is an emerging field that investigates the role of perinatal events – for example pregnancy complications and infections – in the development of neuropsychiatric conditions, such as schizophrenia and mood disorders. Among the implicated pathological mechanisms, perinatal-induced inflammation seems to play a major role and is being considered as a potential target for therapeutic intervention. Bringing together various approaches in the field (preclinical and clinical, epidemiological, immunological and genetic methods), the book discusses the available evidence, the putative mechanisms and the challenges ahead.
Clinical Challenges in the Biopsychosocial Interface
Psychosomatic medicine may be considered to be one of the leading approaches to treating comorbid disorders and conditions. The chapters of this volume are written by experts in the field and present the newest developments in psychosomatic medicine, from basic science to clinical approaches and novel treatments. Discussed are communications with patients suffering from serious illness, basic science and management of fibromyalgia and chronic fatigue. Further psychiatric symptomatology in Huntington's disease and its management as well as coping with losses, grief and mourning in prostate cancer are reviewed. Psychocutaneous diseases, the role of telomeres in stress and mental illness, dimensional psychopharmacology in somatizing patients and many other clinically important areas are also covered. Papers in this publication offer new information on the advances of contemporary psychosomatic medicine in variety of areas previously not sufficiently covered and are of valuable reading for psychiatrists, psychologists, internists, oncologists and primary care specialists.
