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Multiple Sclerosis
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Multiple Sclerosis
Multiple sclerosis has rapidly changed over the last decade into a condition necessitating a multi-disciplinary approach to both its management and understanding. This book reflects all these advances including contributions from genetics, immunology and molecular biology. The many new drugs, both approved or in advanced stages of clinical trials, which give cause for optimism for the treatment of the disease, are described. This new comprehensive work has both editors and contributors that bring together basic science researchers and clinicians from Europe and the USA. A comprehensive reference on multiple sclerosis covering diagnosis, treatment and scientific background. Coverage of emergent drugs which are not in other books, eg Antegrin, as well as current frontline drugs. International group of contributors which includes leading researchers in the field from USA, Switzerland, France, UK and Germany. Based on cutting edge research but stresses the practical issues of diagnosis and treatment needed by neurologists. Comprehensive coverage of primary treatment of the disease process itself and symptomatic therapies, sexual and bladder dysfunction and rehabilitation.
Multiple Sclerosis, 2Ed
Multiple sclerosis is a serious condition to the patient and their family, an awesome task to the clinician who confronts it, and a formidable challenge to the investigator who chooses to research it. With evidence implicating an immunologic basis for lesion pathogenesis and the myelin sheath as the primary target, there has been in recent years, a heavy bias towards a break in self-tolerance and autoimmunity as major mechanisms. This and other immunologic anomalies now figure prominently in several treatment modalities and are presented in a balanced fashion in many of the accompanying chapters. The editors labored long over the composition of the table of contents and contributors. Accordi...
Multiple Sclerosis
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Diseases of the Nervous System
The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of re...
Myelin
My colleagues and I have been gratified by how rapidly the first edition of Myelin has been aeeepted as a standard referenee work by myelin researehers. This is undoubtedly the primary faetor aecounting for the high rate of reeidivism among the authors with respeet to preparation of a seeond edition; eleven of the original twelve contributors were again involved. Four new authors (Wendy Cammer, Marjorie Lees, Ute Traugott, and Seymour Greenfield) have also eontributed to the present volume. This new edition retains many aspects of the format of the original, even including use of the same chapter headings. Thus, comments in the preface to the first edition concerning the level at which mater...
Myelin
The division of the mature mammalian brain and spinal cord into regions of "white" matter and "gray" matter is observable upon the most cursory inspection. Microscopic examination indicates that the "white" matter regions are characterized by a multilamellar sheath (myelin) which sur rounds the axons. A morphologically similar myelin imparts the white color to tracts of the peripheral nervous system, although, as is empha sized throughout the book, there are very significant morphological and chemical differences between central and peripheral myelin. The rapid postnatal accumulation of myelin is temporally associated with increasing functional capacity and presumably indicates some importan...
