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Viral Fitness and Evolution
This book unifies general concepts of plant and animal virus evolution and covers a broad range of topics related to theoretical and experimental aspects of virus population dynamics and viral fitness. Timely topics such as viral mechanisms to cope with antiviral agents, the adaptability of the virus to new hosts, emergence of new viral phenotypes, and the connections between short- and long-term virus evolution are included. By comparing plant and animal viruses, universal mechanisms responsible for fitness variations, viral emergence and disease mechanisms are explored. Although emphasis is put on specific plant and human viral pathogens, relevant similarities and differences to other viruses are highlighted. Additionally, readers will learn more about the adaptability of coronaviruses, including the recently emerged SARS-CoV-2, the causative agent of the COVID-19 pandemic. The book is aimed at students and scientists interested in basic and applied aspects of plant and animal virus population dynamics and evolution.
Quasispecies: From Theory to Experimental Systems
This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.
Women in Virology: 2022
In celebration of International Women's Day 2022, Frontiers in Microbiology are proud to launch this Women in Virology collection, a dedicated Frontiers Research Topic aimed at celebrating the achievements of women in this field. There is continued gender disparity in STEM field. According to UNESCO Institute for Statistics, just 30% of the world's researchers are women. While the number of women attending university is growing, they still represent the minority of doctoral students and researchers. Women remain under-represented in the highest level of academia, holding just 26% of full professorships. As highlighted by UNESCO, science and gender equality are essential to ensure sustainable development.
Virology today in Spain. Selected topics from the XVI Spanish Virology
About this Research Topic Submission closed. Guidelines Recently, our society has experimented that Virology is a changing panorama with a large impact on health, economy, and society. In the post-pandemic times, preparedness for existing and new threats has become a key factor focusing the work of clinical virologists and researchers. This Research Topic is focused on the knowledge and recent experience in viral diseases in the Iberian Peninsula geographical area, neighboring countries - due to climate change - and worldwide - given the ease of communications and the globalization of our societies. For research focussed on plant virology, please see the twinned Research Topic in Frontiers in Microbiology.
Viral Infections and Global Change
A timely exploration of the impact of global change on the emergence, reemergence, and control of vector-borne and zoonotic viral infections From massively destructive "superstorms" to rapidly rising sea levels, the world media is abuzz with talk of the threats to civilization posed by global warming. But one hazard that is rarely discussed is the dramatic rise in the number and magnitude of tropical virus outbreaks among human populations. One need only consider recent developments, such as the spread of chikungunya across southern Europe and dengue in Singapore, Brazil, and the southern United States, to appreciate the seriousness of that threat. Representing a major addition to the world ...
The Picornaviruses
A springboard for developing new approaches to understanding, preventing, and treating picornaviral diseases. • Examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research; encapsulates current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses; and, examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases. • Explores the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth; and, illustrates how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness. • Focuses on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies.
Origin and Evolution of Viruses
New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. - NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution - UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups - SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts
Species of Contagion
Species of Contagion examines the political and social implications of xenotransplantation for bodies, nations, and species. Scientists are demonstrating a renewed interest in developing transplants for humans with tissues from pigs, with the aid of genetic engineering techniques, immunosuppressant drugs, and novel cellular technologies. Yet, some argue that these transspecies promiscuities threaten to enable new viruses to emerge in human populations. Drawing on the later works of Foucault, this book analyses contemporary power relations in animal-to-human transplantation research, ranging across governmental regulation, scientific understandings of infectious disease, and animal ethics. While many xenotransplantation practices resonate with a security approach that renders uncertainty an inherent condition of life and encourages adaptation across species boundaries, government regulation and industry also reinscribe sovereign boundaries of bodies, species, and nations. Species of Contagion illustrates the variation in the cultural and scientific imaginaries that governments and industry bring to bear on the problematic of xenotransplantation.
Virus as Populations
Virus as Populations: Composition, Complexity, Dynamics, and Biological Implications explains fundamental concepts that arise from regarding viruses as complex populations when replicating in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, probability to be transmitted or response to treatment, depend on virus population numbers and in the variations of such population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, new antiviral strategies such as lethal mutagenesis, and extensions...
Single-stranded RNA phages
This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols. Key Features Presents the first full guide to single-stranded RNA phages Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences Demonstrates how RNA phage-derived products have resulted in nanotechnological applications Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies
