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Cellular Therapy
  • Language: en

Cellular Therapy

This book examines the current state and future prospects of cell therapy. An essential guide to the data, basic science, outcome studies and decision-making processes in blood and marrow stem cell transplantation. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians.

Second Generation Cell and Gene-Based Therapies
  • Language: en
  • Pages: 846

Second Generation Cell and Gene-Based Therapies

Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately faci...

Cellular Therapy
  • Language: en
  • Pages: 226

Cellular Therapy

The use of cells for the treatment of a variety of diseases is no longer a dream. Today, blood transfusion, bone marrow transplantation, the use of ex vivo cultured skin in wound healing, and peripheral stern cell transplantation, including the ex vivo expansion of hematopoietic stern cells after high-dose chemo/radiation therapy, are routine. This high standard of knowledge and skills in cell transplantation might also re sult in tackling hitherto untreatable diseases. Organ transplantation is presently the only life-saving treatment for a variety of conditions. Important findings in cell and molecular biol ogy, the identification of hematopoietic, mesenchymal and neuronal stern cells, toge...

Gene and Cell Therapy
  • Language: en
  • Pages: 1154

Gene and Cell Therapy

  • Type: Book
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  • Published: 2008-10-06
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  • Publisher: CRC Press

Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression. New Topics Covered in this Edition: Gene and Cell Therapies for Diabetes and Cardiovascular Diseases Clinical Trials Human Embryonic Stem Cells Tissue Engineering Combined with Cell Therapies Novel Polymers Relevant Nanotechnologies SiRNA Therapeutic Strategies Dendrim...

Cell Therapy
  • Language: en
  • Pages: 334

Cell Therapy

  • Type: Book
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  • Published: 2017-08-25
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  • Publisher: Springer

This volume provides a comprehensive, state-of-the art review of the field of cell therapy. The volume begins with an overview of the breadth of the field and then turns to overviews of imaging technologies that can aid in both safety and efficacy evaluations. The book then turns to numerous contributions detailing the rapidly growing field of stem cell therapies. These sections cover our understanding of the natural roles of stem cells in biology and human disease and then touches on several of the more prominent areas where stem cells are moving rapidly into clinical evaluation including neurodegenerative diseases, muscular dystrophy, cardiac repair, and diabetes. The volume concludes with...

Gene and Cell Therapy: Biology and Applications
  • Language: en
  • Pages: 316

Gene and Cell Therapy: Biology and Applications

  • Type: Book
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  • Published: 2018-09-12
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  • Publisher: Springer

Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail. Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics.

Cell Therapy
  • Language: en
  • Pages: 656

Cell Therapy

Cell therapy is a rapidly developing area, drawing on cell biology, molecular biology, virology, immunology, cell quantitation techniques and biomedical engineering. It has potential in many clinical settings, in the treatment of cancer and other diseases. This volume in the series Cancer: Clinical Science in Practice examines the current state and future prospects of cell therapy, which seems likely to have an even more profound impact on health care than did the production of proteins by recombinant DNA technology. The coverage is broad, including the scientific principles of haematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy, and the principles and practice of cellular immunotherapy. Up-to-date and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.

Cellular Therapies in Cancer
  • Language: en
  • Pages: 182

Cellular Therapies in Cancer

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Handbook of Stem Cell Transplantation and Cellular Therapy Management
  • Language: en
  • Pages: 353

Handbook of Stem Cell Transplantation and Cellular Therapy Management

Handbook of Stem Cell Transplantation and Cellular Therapy Management provides an evidence-based practical guide for clinicians and practitioners who treat cancer patients with these challenging and innovative techniques. The handbook begins with chapters on autologous transplantation for myeloma and lymphoma and allogenic transplantation for leukemia, lymphoma, and myelodysplastic syndrome. Further chapters cover the standards of care for managing adverse events related to acute graft-versus-host disease, chronic graft-versus-host disease, infections of bacterial, fungal, and viral nature, lymphoproliferative disease, pulmonary complications, renal complications, and more clinical issues. C...

Guide to Cell Therapy GxP
  • Language: en
  • Pages: 279

Guide to Cell Therapy GxP

Guide to Cell Therapy GxP is a practical guide to the implementation of quality assurance systems for the successful performance of all cell-based clinical trials. The book covers all information that needs to be included in investigational medicinal product dossier (IMPD), the launching point for any clinical investigation, and beyond. Guide to Cell Therapy GxP bridges a knowledge gap with the inclusion of examples of design of GLP-compliant preclinical studies; design of bioprocesses for autologous/allogeneic therapies; and instruction on how to implement GLP/GMP standards in centers accredited with other quality assurance standards. Guide to Cell Therapy GxP is an essential resource for s...