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Comparing TIMP-1 and Hsp70 in Blood and Saliva as Potential Prognostic Markers in HNSCC
Abstract: (1) Background: Currently, there is no clinically used liquid biomarker in head and neck squamous cell carcinoma (HNSCC) patients. One reason could be the limited shedding of tumor material in early disease stages. Molecular diagnostics assessing both blood and especially saliva could potentially improve the accuracy of biomarkers. In this prospective study, two markers, tissue inhibitor of metalloprotease-1 (TIMP-1) and heat shock protein 70 (Hsp70), were analyzed in HNSCC patients. The purpose of the study was to evaluate differences between saliva and serum as sample material. Further, their prognostic and predictive value and usefulness for early detection was assessed. (2) Met...
A Pattern Language
You can use this book to design a house for yourself with your family; you can use it to work with your neighbors to improve your town and neighborhood; you can use it to design an office, or a workshop, or a public building. And you can use it to guide you in the actual process of construction. After a ten-year silence, Christopher Alexander and his colleagues at the Center for Environmental Structure are now publishing a major statement in the form of three books which will, in their words, "lay the basis for an entirely new approach to architecture, building and planning, which will we hope replace existing ideas and practices entirely." The three books are The Timeless Way of Building, T...
Winter der Gefühle
1805. Laura Magdalen, im Kloster aufgewachsen, inzwischen beim Pfarrerehepaar Schäuffelin lebend soll jetzt zu ihren Eltern ziehen, die sie gar nicht kennt. Wütend macht sie sich auf den Weg. Nur um die Eltern zu pflegen hat man sich an Laura Magdalen erinnert, zuvor wurde nie nach ihr gefragt. Am liebsten würde sie davonlaufen ... Christoph lebt seit dem Tod seiner Eltern bei seiner Tante Olga und seinem Onkel Karl in Stuttgart. Nach einer enttäuschten Liebe verlässt er Stuttgart, um Herzog Georg zu helfen und dabei auf andere Gedanken zu kommen ... Bei einem Ausritt begegnet Christoph das erste Mal Laura Magdalen und ist fasziniert von ihr. Wie stark ihre Zukunft sich verquicken wird ahnen sie zu diesem Zeitpunkt noch nicht. Erst als Laura Magdalen entführt wird, lernen sie und Christoph sich näher kennen und merken allmählich wie ähnlich ihre Vergangenheit doch ist und wie übel ihren Eltern früher mitgespielt wurde. ... welche Leiden, Widrigkeiten und Wirren müssen diese beiden jungen Menschen über sich ergehen lassen, bevor ihnen endlich das längst verdiente Glück zuteil wird?
Family, Ties and Care
Families international – the new milestone How may care be secured—particularly in ageing societies, how may families, relatives and friends support each other and live together beyond market reasons? How can social welfare be secured? How do different countries and different cultures solve the problems they may or may not, now or in days to come, share with other countries and cultures? Families, as is found in this publication by internationally renowned experts, are the base and well of society’s fortune in a humane paradigm. Furthermore, it is the very backbone of lifelong solidarity in inter-generational relations, and the very place where the readiness of taking on care and responsibility are experienced and learned. The publication’s underlying idea opens up two perspectives: on the one hand, differences and similarities in family life forms are chiselled out on the base of an international cooperation. Simultaneously, the international authors are called upon to express their ideas about their own country’s future more distinctly and clearly; thus, distinctions and similarities of the respective paths of development are rather easily perceived.
Telling Stories / Geschichten erzählen
The essays collected in this volume highlight the narrative as a phenomenon inherent in human nature. They examine the likely purpose of artistic and literary expression and its contribution to survival in an early human environment. They also consider the developing interest in shaping experience through the narrative, and investigate the consequent significance of traits acquired throughout the ages for the production and reception of texts. In doing so, the book provides a highly diverse overview of the latest research and debates in this innovative field of research.
The Color of Life
There has been a persistent tradition of enlivening sculptures with color. This book presents five essays on polychromy in classical Greek through contemporary sculpture, along with discussions of over 40 extraordinary polychrome sculptures.
What is Psychotherapeutic Research?
This book marks an important watershed in the development of psychotherapy. It provides examples of how psychotherapeutic research and the abilities to carry it out can help the practising psychotherapist. A lack of relative knowledge of research in psychotherapy, a history of apparent defensiveness is being evaluated, and a reluctance to work with universities has developed in psychotherapy. The papers represent a cross-section of current research thinking from within the UKCP, North America and Continental Europe. It will prove useful for students and practitioners of psychotherapy, as well as those more traditionally engaged in psychotherapeutic research.The book has been divided into five sections: Section One outlines what is meant by psychotherapeutic research and gives an overview of the features of different research methods. Section Two describes how to get started in the use of qualitative and quantitative methods. Section Three focuses on research into the process of psychotherapy.
