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Poeresia: Boemia
Poeresia: poesia e heresia Venha cá, não tenha medo. Coloque para fora o que guarda aí há tanto tempo. Um dia te disseram para esconder isso aí, que era piegas, tosco, não digno de ser revelado. Ficou armazenado nas mais doces e amargas memórias. Com o tempo, pareceram sem gosto, neutras, desprovidas do sentido que tinham quando você ousou escrever. Esconderam do mundo suas palavras, os sentimentos mais nobres e os mais polêmicos. Agora, eles maturaram, fermentaram e destilaram: o puro malte, o doce vinho, a aguardente. Sentimentos há muito de molho que, finalmente, podem retornar com mais força e com mais vigor. O tempo não os deixou sem sentido. Apenas são vistos sob o olhar do tempo.
Thermodynamics and Kinetics of Drug Binding
This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.
Molecular Dynamics and Machine Learning in Drug Discovery
Dr. Sergio Decherchi and Dr. Andrea Cavalli are co-founders of BiKi Technologies s.r.l. - a company that commercializes a Molecular Dynamics-based software suite for drug discovery. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Computational Methods for Estimating the Kinetic Parameters of Biological Systems
This detailed book provides an overview of various classes of computational techniques, including machine learning techniques, commonly used for evaluating kinetic parameters of biological systems. Focusing on three distinct situations, the volume covers the prediction of the kinetics of enzymatic reactions, the prediction of the kinetics of protein-protein or protein-ligand interactions (binding rates, dissociation rates, binding affinities), and the prediction of relatively large set of kinetic rates of reactions usually found in quantitative models of large biological networks. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of expert implementation advice that leads to successful results. Authoritative and practical, Computational Methods for Estimating the Kinetic Parameters of Biological Systems will be of great interest for researchers working through the challenge of identifying the best type of algorithm and who would like to use or develop a computational method for the estimation of kinetic parameters.
Redox-Active Therapeutics
This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neg...
Biolubricants
Lubricants are essential in engineering, however more sustainable formulations are needed to avoid adverse effects on the ecosystem. Bio-based lubricant formulations present a promising solution. Biolubricants: Science and technology is a comprehensive, interdisciplinary and timely review of this important subject.Initial chapters address the principles of lubrication, before systematically reviewing fossil and bio-based feedstock resources for biodegradable lubricants. Further chapters describe catalytic, (bio) chemical functionalisation processes for transformation of feedstocks into commercial products, product development, relevant legislation, life cycle assessment, major product groups...
Lucifer - The First Angel
Lucifer - The First Angel 'Lucifer - The First Angel' is a brutal epic about how and why the greatest hero of God fell to darkness. From the dawn of creation up to the ruin of all existence, it reveals the true nature of Good and Evil, the meaning of Life and Death, and that even in Hell it is possible to find honor and sacrifice. The author carried out an extensive detailed research on archaeological discoveries and teachings of Taoism, Buddhism, Jewish Christianity, Islam, Brahmanism, among other ancient beliefs and philosophies.
Restorative Justice and the Law
Restorative justice has developed from a barely known term to a central role in debates on the future of criminal justice. But as it has moved into the mainstream so new tensions and issues have emerged as it becomes increasingly integrated into normal practice, and part of broader legal and judicial systems both in common law countries and those with centralised legal systems. The purpose of this book is to explore this developing relationship between the concepts and practice of restorative justice on the one hand, and the law and legal systems on the other. Amongst the questions it addresses are the following: how are informal processes to be juxtaposed with formal procedures? what is the appropriate relationship between voluntarism and coercion? how can the procedures and practices of restorative justice be combined with legal standards, safeguards and precepts?
