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Primary Progressive Multiple Sclerosis
"Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin i...
Central Nerve Plexus Injury
This unique volume presents the first successful surgical strategy to repair the spinal root and the associated spinal cord injury that follows from severe traction injuries to the brachial and lumbosacral nerve plexus. The basic science background to this novel surgical technique is described, and the contemporary palliative procedures as well as clinical and ancillary assessments are given together with a meticulous description of the functional outcome of the surgery. Covering the research that led to the author''s pioneering application of this surgical technique to the clinical human situation, the book provides a comprehensive overview of the authorOCOs work as a leading basic scientist and nerve surgeon. It is a journey from ideas born in the laboratory to successful application to a difficult human problem involving loss of function and severe pain from a certain type of spinal cord injury. The first step leading to the treatment of a severe and devastating spinal cord injury has been taken and is described in this book."
Nuclei with Z=1....54
Volume I/22A is the first of two volumes dedicated to nuclear binding energies and atomic masses of all nuclei. Related properties like the separation energies of single nucleons, or groups of nucleons, Q-values of alpha and beta nuclear reactions, and parameters of the residual interaction between nucleons, are considered as well. Also the experimental values are compared to the results of various model calculations. This comparison of experimental and theoretical results may help in the further development of nuclear theory. The data presented will also be of great significance for astrophysics and the understanding of the production of elements in the early universe. The present compilati...
Traumatic Injuries in the Nervous System
This Research Topic surrounds the information presented at the upcoming conference Neurotrama Symposium held at the Centre for Trauma Research, September 15-16 2010. Traumatic injury to the central nervous system (CNS) is the leading cause of death and disability for people up to about 40 years of age. Examples and experiences of CNS trauma and medical care during historic and ongoing wars will be given, referring to the early history of Karolinska Institutet (KI).
Nmr Probeheads For Biophysical And Biomedical Experiments: Theoretical Principles And Practical Guidelines (2nd Edition)
NMR Probeheads for Biophysical and Biomedical Experiments 2nd Edition is essential reading for anyone in the field of NMR or MRI, from students to medical or biological scientists performing experiments under certain physical and/or geometrical conditions, unattainable by conventional or available probes. The material guides the reader through the most basic and comprehensive stages in accomplishing a correct probe design, from a very basic oscillating circuit to much more elaborate designs.This new edition has been revised and updated to include a chapter dedicated to RF components, which are commonly used for probes realization and their frequency-dependent characteristics. Another completely revised chapter concerns the multiple coil systems and discusses arrays coils, different decoupling methods, and some principles for interfacing coils with low-noise preamplifiers. The principles of linear circuit analysis are presented in a dedicated chapter. Last but not least, accompanying files containing updated software for probe design have been made available from the publisher's website.
MRI from Picture to Proton
Presents the basics of MR practice and theory as the practitioner first meets them.
Quantitative MRI of the Spinal Cord
Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply t...
Computer-Aided Tissue Engineering
The recent revolution in the biological sciences and bioengineering, along with the advancements of modern design and manufacturing, biomaterials, biology, and biomedicine, have brought about the new field of computer-aided tissue engineering. Advances in this fascinating new area of study encompass broad applications in large-scale tissue engineering fabrication, artificial organs, orthopaedic implants, and biological chips. Computer-Aided Tissue Engineering highlights the interdisciplinary nature of this topic and reviews the current state of computer-aided three-dimensional tissue modeling, tissue classification, and tissue fabrication and implantation. Particular focus is placed on rapid...
A Primer on PDEs
This book is designed as an advanced undergraduate or a first-year graduate course for students from various disciplines like applied mathematics, physics, engineering. It has evolved while teaching courses on partial differential equations during the last decade at the Politecnico of Milan. The main purpose of these courses was twofold: on the one hand, to train the students to appreciate the interplay between theory and modelling in problems arising in the applied sciences and on the other hand to give them a solid background for numerical methods, such as finite differences and finite elements.
