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Biophysical and Computational Tools in Drug Discovery
This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design. Divided into 10 chapters, the book discusses about the role of structural biology in drug discovery, and offers useful application cases of several biophysical and computational methods, including time-resolved fluorometry (TRF) with Förster resonance energy transfer (FRET), X-Ray crystallography, nuclear magnetic resonance spectroscopy, mass spectroscopy, generative machine learning for inverse molecular design, quantum mechanics/molecular mechanics (QM/MM,ONIOM) and quantum molecular dynamics (QMT) methods. Particular attention is given to computational search techniques applied to peptide vaccines using novel mathematical descriptors and structure and ligand-based virtual screening techniques in drug discovery research. Given its scope, the book is a valuable resource for students, researchers and professionals from pharmaceutical industry interested in drug design and discovery.
The ELSI Handbook of Nanotechnology
This Handbook focuses on the recent advancements in Safety, Risk, Ethical Society and Legal Implications (ESLI) as well as its commercialization of nanotechnology, such as manufacturing. Nano is moving out of its relaxation phase of scientific route, and as new products go to market, organizations all over the world, as well as the general public, are discussing the environmental and health issues associated with nanotechnology. Nongovernmental science organizations have long since reacted; however, now the social sciences have begun to study the cultural portent of nanotechnology. Societal concerns and their newly constructed concepts, show nanoscience interconnected with the economy, ecology, health, and governance. This handbook addresses these new challenges and is divided into 7 sections: Nanomaterials and the Environment; Life Cycle Environmental Implications of Nanomanufacturing; Bioavailability and Toxicity of Manufactured Nanoparticles in Terrestrial Environments; Occupational Health Hazards of Nanoparticles; Ethical Issues in Nanotechnology; Commercialization of Nanotechnology; Legalization of Nanotechnology.
Nuclear Magnetic Resonance
As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids...
Surfactants in Solution
This and its companion volumes 7,8, and 9 document the proceedings of the 6th International Symposium on Surfactants in Solution (SIS) held in New Delhi, India, August 18-22, 1986 under the joint auspices of the Indian Society for Surface Science and Technology, and Indian Institute of Technology, Delhi. As this symposium was a landmark -- it represented the tenth anniversary of this series of symposia -- so it is very apropos to reflect on how these symposia have evolved to their present size and status. The pedigree of this series of symposia goes back to 1976 when the premier symposium in this series was held. Actually in 1976 it was a modest start and it was not possible at that time to ...
Bioinspired Intelligent Nanostructured Interfacial Materials
Intelligent materials are emerging composite functional materials that have boomed since the 1990s. The intelligent material system, involving a multitude of structures and functions, combines studies that explore nature, mimic nature and surpass nature. It also provides novel ideas, new theories, and cutting-edge methodologies for the innovation of science and technology. Thus, mimicking the micro/nanostructures and functions found in nature will build a bridge between biology and technology, which may provide inspirations for solving today's technological problems. This book gives a complementary introduction about natural and artificial micro/nanoscale interfacial materials, devoting larg...
Epigenetic Regulation of Skin Development and Regeneration
This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration that target the epigenome. Part of the highly successful Stem Cells and Regenerative Medicine series, Epigenetic Regulation of Skin Development and Regeneration uncovers the fundamental significance of epigenetic mechanisms in skin development and regeneration, and emphasizes the development of new therapies for a number of skin disorders, such as pathological conditions of epidermal differentiation, pigmentation and carcinogenesis. At least six categories of researchers will find this book essential, including stem cell, developmental, hair follicle or molecular biologists, and gerontologists or clinical dermatologists.
Lions 324B1 District Directory (2004-05)
Released by District Governor Lion P. Saradhamani
Lions 324A2 District Directory (2016-17)
Lions District Directory for the Centennial Year 2016-17 for District 324A2 was released by its District Governor MJF Lion Dr Venkataraman, in September. This Digital Edition gives all the information of it, in the Mobile Phone and EReaders.
Crown Ethers and Phase Transfer Catalysis in Polymer Science
Phase transfer catalysis or interfacial catalysis is a syn thetic technique involving transport of an organic or inorganic salt from a solid or aqueous phase into an organic liquid where reaction with an organic-soluble substrate takes place. Over the past 15 years there has been an enormous amount of effort invested in the development of this technique in organic synthe sis. Several books and numerous review articles have appeared summarizing applications in which low molecular weight catalysts are employed. These generally include either crown ethers or onium salts of various kinds. While the term phase transfer catalysis is relatively new, the concept of using a phasetrans fer agent (PTA)...
Sun Protection in Man
"Sun Protection in Man" looks at the beneficial and harmful effects of solar radiation. The physiological consequences of sun exposure have been systematically studied starting at the end of the nineteenth century and we now have accumulated knowledge about how Caucasian and Asian skins reacts to solar radiation. The chemical effects of solar ultraviolet radiation have been analyzed with particular emphasis during the second half of the twentieth century. Research on micro-organisms has allowed us to understand the mechanisms of UV-induced mutagenesis and photosensitization. Studies with laboratory rodents have opened the path to the understanding of UV-induced immune-depression, carcinogene...
