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Design and Analysis of Non-Inferiority Trials
The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the issues involved in the design of a non-inferiority tr
Juvenile Delinquency: An Integrated Approach
Juvenile Delinquency: An Integrated Approach, Second Edition offers a comprehensive introduction to juvenile delinquency. Now in a more concise and accessible format, this text cultivates an understanding of juvenile delinquency by examining and linking key sociological and criminological theories and research. Biological and psychological apporaches to delinquency are covered, as well as responses to deliquent behavior includuing prevention, early intervention, and contemporary juvenile justice.
Demographic Forecasting
Demographic Forecasting introduces new statistical tools that can greatly improve forecasts of population death rates. Mortality forecasting is used in a wide variety of academic fields, and for policymaking in global health, social security and retirement planning, and other areas. Federico Girosi and Gary King provide an innovative framework for forecasting age-sex-country-cause-specific variables that makes it possible to incorporate more information than standard approaches. These new methods more generally make it possible to include different explanatory variables in a time-series regression for each cross section while still borrowing strength from one regression to improve the estima...
Annual Progress in Child Psychiatry and Child Development, 1991
The twenty-fourth volume of this acclaimed series presents 30 articles in seven major areas: developmental studies; stress and vulnerability; language studies; temperament studies; clinical syndromes; diagnosis and treatment; and psychosocial issues. The articles are of two types: original work that holds promise of furthering progress in the study of the child, and review pieces that offer an insightful systematic perspective on a significant area. Each article appears in its entirely with all original tables, figures and bibliographies.
Theory of Drug Development
Theory of Drug Development presents a formal quantitative framework for understanding drug development that goes beyond simply describing the properties of the statistics in individual studies. It examines the drug development process from the perspectives of drug companies and regulatory agencies. By quantifying various ideas underlying drug development, the book shows how to systematically address problems, such as: Sizing a phase 2 trial and choosing the range of p-values that will trigger a follow-up phase 3 trial Deciding whether a drug should receive marketing approval based on its phase 2/3 development program and recent experience with other drugs in the same clinical area Determinin...
Health Implications of Perchlorate Ingestion
Perchlorateâ€"a powerful oxidant used in solid rocket fuels by the military and aerospace industryâ€"has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by inhibiting the uptake of iodide by the thyroid. Thyroid hormones are critical for normal growth and development of the central nervous system of fetuses and infants. This report evaluates the potential health effects of perchlorate and the scientific underpinnings of the 2002 draft risk assessment issued by the U.S. Environmental Protection Agency (EPA). The report finds that the body c...
Randomized Clinical Trials of Nonpharmacological Treatments
Nonpharmacological treatments include a wide variety of treatments such as surgery, technical procedures, implantable and non-implantable devices, rehabilitation, psychotherapy, and behavioral interventions. Unlike pharmacological treatments, these have no specific requirements for approval. Consequently, they can be widely proposed in clinical pra
Meta-Analysis for Public Management and Policy
Meta-Analysis for Public Management and Policy is a groundbreaking book that introduces meta-analysis and includes proven techniques for research in public management and policy. The book provides statistical approaches to meta-analysis most useful for public policy and management and features five examples of original meta-analyses of important questions in public management and policy conducted by the author and his team. These original studies show step-by-step how to conduct a meta-analysis and contribute original research on ...
Statistics
Statistics: Unlocking the Power of Data, 2nd Edition continues to utilize these intuitive methods like randomization and bootstrap intervals to introduce the fundamental idea of statistical inference. These methods are brought to life through authentically relevant examples, enabled through easy to use statistical software, and are accessible at very early stages of a course. The program includes the more traditional methods like t-tests, chi-square texts, etc. but only after students have developed a strong intuitive understanding of inference through randomization methods. The focus throughout is on data analysis and the primary goal is to enable students to effectively collect data, analyze data, and interpret conclusions drawn from data. The program is driven by real data and real applications.
Picturing the Uncertain World
In his entertaining and informative book Graphic Discovery, Howard Wainer unlocked the power of graphical display to make complex problems clear. Now he's back with Picturing the Uncertain World, a book that explores how graphs can serve as maps to guide us when the information we have is ambiguous or incomplete. Using a visually diverse sampling of graphical display, from heartrending autobiographical displays of genocide in the Kovno ghetto to the "Pie Chart of Mystery" in a New Yorker cartoon, Wainer illustrates the many ways graphs can be used--and misused--as we try to make sense of an uncertain world. Picturing the Uncertain World takes readers on an extraordinary graphical adventure, ...
