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Ma Vie en Noir
I wrote this book urged by the overwhelming desire that arises towards the end of life to recapitulate the past. My goal was to summarize my experience of practicing science at the end of the 20th and early 21st centuries in Argentina, a country located far away from the world’s leading scientific centers. In the book, I summarize the intricacies of the pineal gland (“the stone of madness”) as historical, mystical and medical entity and its entry in contemporary medicine with the description of melatonin. I also reflect on how being associated with an unexplored subject at the beginning of his scientific career impacts the life of a scientist throughout their entire life. Today we know...
Melatonin
Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in circadian rhythm and regulation of diverse body functions. Levels of melatonin start to increase prior to bedtime. Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This important book presents a full spectrum of research on melatonin and is destined to become an essential reference for anyone interested in melatonin.
GABA and Sleep
GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. The GABA system is, therefore, of prime clinical relevance for the therapy of insomnia. The focus of this volume is on the neuropsychopharmacology and the clinical impact of the GABA system in regulating sleep and wakefulness. It presents molecular, neuropharmacological, systems-biological and clinical approaches to the understanding of the mechanism of action of GABA and GABAergic drugs. It also explores the role of GABA in the basic drives that affect sleep, and the influences that adapt sleep and wakefulness to external events.
Human Brain
Understanding the human brain is essential to become a well-informed, modern citizen. As always, nonsense proliferates around popular topics. The author of the human Brain is a physician-writer, an expert navigator who can steer you away from nonsense, and help you understand practical details about brain function and disease. This is a big book with big ideas, so be prepared to read, re-read and then keep the book as reference. Read topics from the book by clicking links to the left. Dr. Gislason's Preface "My goal in writing this book is to provide a guide to intervention in disorders of brain function. The brain is the organ of the mind. Therefore, molecular influences that alter the func...
Focus on Alzheimer's Disease Research
Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. The most common form of dementia among older people is Alzheimer's disease (AD), which involves the parts of the brain that control thought, memory, and language. Age is the most important known risk factor for AD. The number of people with the disease doubles every 5 years beyond age 65. AD is a slow disease, starting with mild memory problems and ending with severe brain damage. The course the disease takes and how fast changes occur vary from person to person. On average, AD patients live from 8 to 10 years after they are diagnosed, though the disease can last for as many as 20 years. Cur...
Sleep and Clocks in Aging and Longevity
This edited volume focuses on the interplay between sleep and circadian rhythms with health, aging and longevity. Sleep is absolutely important for human health and survival, as insufficient sleep is associated with a plethora of conditions, including the poor quality of life, onset of several diseases, and premature death. The sleep–wake cycle is an evolutionary conserved neurobiological phenomenon, and is a prominent manifestation of the biological clocks localised in the suprachiasmatic nucleus (SCN). Understanding bidirectional relationship between sleep and circadian rhythms is of utmost importance and urgency, especially in the context of modern lifestyle where sleep is often out of ...
Management of Sleep Disorders in Psychiatry
Management of Sleep Disorders in Psychiatry provides the most comprehensive and evidence-based review or the clinical management of DSM-V® based sleep-wake disorders in patients with psychiatric disorders. Readers will be informed on the basics of sleep medicine, clinical features and treatment of DSM-V® sleep-wake disorders, and evidence-based management of sleep disorders commonly associated with a range of DSM-V® based psychiatric disorders. This is a clinically oriented book that provides case vignettes, key clinical pearls, and a self-assessment section to help readers prepare themselves for board and certification exams. Intended for psychiatry trainees and practitioners, this book could also prove useful for clinical psychologists, behavioral sleep medicine specialists, general sleep practitioners, sleep specialists and neurologists due to its wide range of clinical topics. Book jacket.
Melatonin in the Promotion of Health
Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism and the health of humans. This volume provides a wide variety of expert reviews on the biology of melatonin relevant to health. Beginning with a history of melatonin and its relation to circadian rhythms, the book examines its use in a host of applications, including gastrointestinal diseases, anesthesia and surgery, bone health, breast cancer, cardiovascular diseases, diabetes, and age-related macular degeneration and uveitis. It also examines applications related to melanoma, solar skin damage, collagen synthesis, the prevention of DNA damage, mental disorders, sleep, and issues related to jet lag and shift work.
