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Strategies to Mitigate the Toxicity of Cancer Therapeutics
Strategies to Mitigate the Toxicity of Cancer Therapeutics, Volume 155 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters, each of which is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Cancer Research series Includes the latest information on Strategies to Mitigate the Toxicity of Cancer Therapeutics
Autophagy and Senescence in Cancer Therapy
Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence
Autophagy
There is currently a great deal of interest in autophagy, a process whereby a cell digests its constituents to generate energy and metabolic precursors under conditions of stress such as nutrient deprivation. Autophagy may serve as a mechanism for protection of the tumor cell from the effects of radiation and chemotherapy, but may also mediate tumor cell death in response to these challenges. Accumulating evidence indicates that autophagy is also a fundamental characteristic of stem cells, including tumor stem cells. As tumor stem cells are likely to play a central role in tumor dormancy, it appears that autophagy could contribute to the capacity of tumor stem cells to survive for extended periods of time in a dormant state and eventually give rise to recurrent tumors that are primary determinants of morbidity and mortality in cancer patients.
The Flexible Enterprise
The Practical Guide to Business Change Companies need to continually adapt to changing conditions in order to survive. If you want more for your company than mere survival, if you want your firm to grow, thrive, and dominate its markets, you'll need to grow beyond knee-jerk responses and conventional wisdom. You'll need the flexibility to change again and again—not just to compensate for tough turns in the business cycle, but to take full advantage of the things your company does best. In The Flexible Enterprise, you'll find a proven methodology for managing repeated change and building on your company's strengths as you adjust to changing market needs. This highly practical guide recogniz...
Apoptosis, Senescence and Cancer
Provides insight into established practices and research into apoptosis and senescence by examining techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. This book concludes with established cancer therapies.
Lotus Notes 3 Revealed!
Lotus Notes 3 is the hottest tool in the evolving dynamics of organizational communications. Gewirtz provides valuable insights on managing projects, increasing productivity, and taking full advantage of the power of Notes across applications and platforms.
How to Save Jobs
Provided free online for downloading through a grant from Zatz Publishing. Everyone's busy, so here's a quick cheat-sheet: If you take anything at all away from this book, let it be this: the world has changed radically since our parents' time. We can't approach jobs in America the way we did in past decades. If you want to really understand how much everything has changed, you'll want to read Part I, "The state of jobs in America" For an in-depth understanding of our health care challenges and some possible solutions, read Chapter 8, "The health care hostage crisis" and Chapter 13, "How to save health care." If you're a policy-maker or are interested in innovative ideas for reinventing business, reinvigorating work, and reawakening the American dream, read Part II, "Policy ideas that could save jobs." If you're an individual trying to make ends meet or a business owner or manager who doesn't have time to wait for Washington to get its act together, read Part III, "Tips & techniques you can use right now." Of course, if you really want to understand how to save jobs, read the whole book. It's quite a story.
Unlikely Partners
With Deng Xiaoping’s blessing, Mao’s successors scoured the globe for fresh ideas to launch domestic prosperity and global economic power. Yet China’s government did not publicize its engagement with Western-style innovations, claiming instead that economic reinvention was the Party’s achievement alone. Julian Gewirtz sets forth the truer story.
