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Architecture and Science-Fiction Film
The home is one of our most enduring human paradoxes and is brought to light tellingly in science-fiction (SF) writing and film. However, while similarities and crossovers between architecture and SF have proliferated throughout the past century, the home is often overshadowed by the spectacle of 'otherness'. The study of the familiar (home) within the alien (SF) creates a unique cultural lens through which to reflect on our current architectural condition. SF has always been linked with alienation; however, the conditions of such alienation, and hence notions of home, have evidently changed. There is often a perceived comprehension of the familiar that atrophies the inquisitive and interpretive processes commonly activated when confronting the unfamiliar. Thus, by utilizing the estranging qualities of SF to look at a concept inherently linked to its perceived opposite - the home - a unique critical analysis with particular relevance for contemporary architecture is made possible.
Identity, Diplomacy and Design
What is the future of diplomacy for Canada in the Age of Reconciliation? What is Canada's identity abroad as a colonial nation state? This booklet is a summary of an undergraduate design studio at the University of Waterloo School of Architecture in collaboration with Global Affairs Canada during the Fall of 2022 that asked these questions. Conceived as a pilot studio to examine pressing questions surrounding the relationship between Canadian international diplomacy and design, the studio traveled to Ottawa and Mexico City to reflect on some of the challenges and opportunities facing designers in a rapidly changing world.
Tumors of the Central Nervous System, Volume 4
This volume mainly contains information on the diagnosis, therapy, and prognosis of brain tumors. Insights on the understanding of molecular pathways involved in tumor biology are explained, which should lead to the development of effective drugs. Information on pathways (e.g., hedgehog) facilitates targeted therapies in cancer. Tumor models are also presented, which utilize expression data, pathway sensitivity, and genetic abnormalities, representing targets in cancer. For example, rat model of malignant brain tumors using implantation of doxorubicin with drug eluting beads for delivery is explained. The future of pathway-driven therapies for tumors is summarized. The importance of personal...
Drug Delivery to the Brain
The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper ...
Tumors of the Central Nervous System, Volume 2
Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.
Sessional Papers
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Architectures of Hiding
Architecture manifests as a space of concealment and unconcealment, lethe and alêtheia, enclosure and disclosure, where its making and agency are both hidden and revealed. With an urgency to amplify narratives that are overlooked, silenced and unacknowledged in and by architectural spaces, histories and theories, this book contends the need for a critical study of hiding in the context of architectural processes. It urges the understanding of inherent opportunities, power structures and covert strategies, whether socio-cultural, geo-political, environmental or economic, as they are related to their hidescapes – the constructed landscapes of our built environments participating in the arch...
