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Principles of Computational Modelling in Neuroscience
Learn to use computational modelling techniques to understand the nervous system at all levels, from ion channels to networks.
Synaptic Plasticity in Neurodegenerative Disorders
This book explores the pivotal role of synaptic plasticity in the pathogenesis, progression, and potential treatment of neurodegenerative disorders. The initial chapter provides an in-depth understanding of the complexity and impact of neurodegenerative conditions. It discusses the association of mitochondrial dysfunction, epigenetic influences, and neuroinflammation with synaptic plasticity in neurodegenerative diseases. The following chapters review the dynamic changes that occur at the cellular and synaptic levels in Parkinson's disease, Alzheimer's disease, and Huntington's disease, paving the way for innovative therapeutic strategies. Furthermore, the book presents various computational...
Neuronal Information Processing, From Biological Data To Modelling And Application
Recent developments in the neurosciences have considerably modified our knowledge of both the operating modes of neurons and information processing in the cortex. Multi-unit recordings have enabled temporal correlations to be detected, within temporal windows of the order of 1ms. Oscillations corresponding to a quasi-periodic spike-giving, synchronized over several visual cortical areas, have been observed in anaesthesized cats and monkeys. Recent studies have also focused on the role played by the dendritic arborization.These developments have led to considerable interest in a coding scheme which relies on precise spatio-temporal patterns from both the theoretical and experimental points of...
Computational Physiology
This open access volume compiles student reports from the 2022 Simula Summer School in Computational Physiology. The reports provide an overview of some tools available to model physiology in excitable tissues across scales and scientific questions. In 2022, Simula held the eighth annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). Each year, the course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. Group research projects conducted by graduate students from around the world result in reports addressing problems of physiological importance. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier studies. Reports from seven of the summer projects are included as separate chapters. The topics represented include multiscale mechanics, electrophysiology, pharmacology, and machine learning.
Emergent Neural Computational Architectures Based on Neuroscience
It is generally understood that the present approachs to computing do not have the performance, flexibility, and reliability of biological information processing systems. Although there is a comprehensive body of knowledge regarding how information processing occurs in the brain and central nervous system this has had little impact on mainstream computing so far. This book presents a broad spectrum of current research into biologically inspired computational systems and thus contributes towards developing new computational approaches based on neuroscience. The 39 revised full papers by leading researchers were carefully selected and reviewed for inclusion in this anthology. Besides an introductory overview by the volume editors, the book offers topical parts on modular organization and robustness, timing and synchronization, and learning and memory storage.
Disorders of Brain, Behavior, and Cognition: The Neurocomputational Perspective
This book contains selected contributions of papers, many presented at the Second International Workshop on Neural Modeling of Brain Disorders, as well as a few additional papers on related topics, including a wide range of presentations describing computational models of neurological, neuropsychological and psychiatric disorders. It is a unique, comprehensive review of the state-of-the-art of modeling cognitive and brain disorders, appealing to a multidisciplinary audience of clinicians, psychologists, neuroscientists, cognitive scientists, computer scientists, and other neural network researchers. The rest of the book is organized along four main themes, involving memory, neuropsychological, neurological and psychiatric disorders. In general, the cognitive disorders and these psychiatric diseases traditionally regarded as "functional" were modeled along functional lines, while those disorders traditionally viewed as "organic" neurological diseases generally drew more from knowledge of the underlying neurobiology and pathophysiology.
Neural Nets
This book constitutes the thoroughly refereed postproceedings of the 16th Italian Workshop on Neural Nets, WIRN 2005, as well as the satellite International Workshop on Natural and Artificial Immune Systems, NAIS 2005, held in Vietri sul Mare, Italy in June 2005. The 41 revised papers presented together with a lecture by the winner of the Premio Caianiello award were carefully reviewed and improved during two rounds of selection and refereeing.
Artificial Neural Networks — ICANN 2002
The International Conferences on Arti?cial Neural Networks, ICANN, have been held annually since 1991 and over the years have become the major European meeting in neural networks. This proceedings volume contains all the papers presented at ICANN 2002, the 12th ICANN conference, held in August 28– 30, 2002 at the Escuela T ́ecnica Superior de Inform ́atica of the Universidad Aut ́onoma de Madrid and organized by its Neural Networks group. ICANN 2002 received a very high number of contributions, more than 450. Almost all papers were revised by three independent reviewers, selected among the more than 240 serving at this year’s ICANN, and 221 papers were ?nally selected for publication in these proceedings (due to space considerations, quite a few good contributions had to be left out). I would like to thank the Program Committee and all the reviewers for the great collective e?ort and for helping us to have a high quality conference.
Synaptic Circuits and Functions in Bio-inspired Integrated Architectures
Based upon the most advanced human-made technology on this planet, CMOS integrated circuit technology, this dissertation examines the design of hardware components and systems to establish a technological foundation for the application of future breakthroughs in the intersection of AI and neuroscience. Humans have long imagined machines, robots, and computers that learn and display intelligence akin to animals and themselves. To advance the development of these machines, specialised research in custom-built hardware designed for specific types of computation, which mirrors the structure of powerful biological nervous systems, is especially important. This dissertation is driven by the quest ...
