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Modern Acetylene Chemistry
This comprehensive handbook presents the full potential of modern acetylene chemistry, from organic synthesis through materials science to bioorganic chemistry. K. Houk, H. Hopf, P. Stang, K. M. Nicholas, N. Schore, M. Regitz, K. C. Nicolaou, R. Gleiter, L. Scott, R. Grubbs, H. Iwamura, J. Moore, and F. Diederich - internationally renowned authors introduce the reader, in a didactically skilful manner, to the state-of-the-art in alkyne chemistry. Emphasis is placed on presenting carefully selected and instructive examples as well as essential references to the original literature. Special benefits: Each chapter is rounded off by useful experimental procedures.
Modern Mass Spectrometry
I Reactivity: E. Uggerud: Physical Organic Chemistry of the Gas Phase. Reactivity Trends for Organic Cations.- S. Petrie, D.K. Bohme: Mass Spectrometric Approaches to Interstellar Chemistry.- F. Turecek: Transient Intermediates of Chemical Reactions by Neutralization-Reionization Mass Spectrometry.- II Metalorganic Chemistry: D. Schröder, H. Schwarz: Diastereoselective Effects in Gas-Phase Ion Chemistry.- D.A. Plattner: Metalorganic Chemistry in the Gas Phase: Insight into Catalysis.- III Mass Spectrometric Methodology: T. Wyttenbach, M.T. Bowers: Gas-Phase Conformations: The Ion Mobility/Ion Chromatography Method.- P.B. Armentrout: Threshold Collision-Induced Dissociations for the Determination of Accurate Gas-Phase Binding Energies and Reaction Barriers.- IV Medicinal Chemistry: S.A. Trauger, T. Junker, G. Siuzdak: Investigating Viral Proteins and Intact Viruses with Mass Spectrometry M. Brönstrup: High-Throughput Mass Spectrometry for Compound Characterization in Drug Discovery.
Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma
Abstract: Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers. The biallelic inactivation of the von Hippel-Lindau tumor suppressor gene (VHL) is the truncal driver mutation of most cases of ccRCC. Cancer cells are metabolically reprogrammed and excrete modified nucleosides in larger amounts due to their increased RNA turnover. Modified nucleosides occur in RNAs and cannot be recycled by salvage pathways. Their potential as biomarkers has been demonstrated for breast or pancreatic cancer. To assess their suitability as biomarkers in ccRCC, we used an established murine ccRCC model, harboring Vhl, Trp53 and Rb1 (VPR) knockouts. Cell culture media of this ccRCC model an...
SAP on the Cloud
This book offers a comprehensive guide to implementing SAP and HANA on private, public and hybrid clouds. Cloud computing has transformed the way organizations run their IT infrastructures: the shift from legacy monolithic mainframes and UNIX platforms to cloud based infrastructures offering ubiquitous access to critical information, elastic provisioning and drastic cost savings has made cloud an essential part of every organization’s business strategy. Cloud based services have evolved from simple file sharing, email and messaging utilities in the past, to the current situation, where their improved technical capabilities and SLAs make running mission-critical applications such as SAP pos...
Strategy, Organization and Performance Management
Designing effective organizations is a key challenge for companies in particular in the fast-moving business world of today. The late 1990s and early 2000s have seen multiple Organization Management innovations applied successfully such as Business Process Outsourcing, Shared Services and Offshoring. Advanced techniques such as Balanced Scorecards and integrated Planning Systems have become effective enablers for strategy execution. This book spans a framework from strategy definition and designing strategy-compliant organizations to monitoring effective implementation and Performance Management. On this journey basic principles of Organization Management are discussed in detail and at the s...
Mass Spectrometric Analysis of Cucurbitacins and Dihydrocucurbitacins from the Tuber of Citrullus Naudinianus
Abstract: The vast pool of structurally and functionally distinct secondary metabolites (i.e., natural products (NPs)) is constantly being expanded, a process also driven by the rapid progress in the development of analytical techniques. Such NPs often show potent biological activities and are therefore prime candidates for drug development and medical applications. The ethyl acetate extract of the tuber of Citrullus naudinianus (C. naudinianus), an African melon with edible fruits and seeds, shows in vitro immunomodulatory activity presumably elicited by cucurbitacins that are known major constituents of this plant. Further potentially immunomodulatory cucurbitacins or cucurbitacin derivati...
Inverting the Paradox of Excellence
Drawing lessons from one of the best models of success, the evolutionary model, this book explains why an organization must actively monitor the market environment and competitors to ascertain excellence and reconfigure and reframe continuously. It introduces the patterns and anti-patterns of excellence and includes detailed case studies based on different variations, including structure variations, shared values variations, and staff variations. The book includes case history segments from Toyota, Acer, eBay, Cisco, Blackberry, Samsung, Volvo, Charles Schwab, McDonalds, Starbucks, Google, Disney, and NUMMI; as well as detailed case histories of GE, IBM, and UPS.
Organic Synthesis
A concise reference that summarizes the most important current developments in organic synthesis.
