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The Retinoids
The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
Retinoids in Mammalian Reproduction, with an Initial Scoping Effort to Identify Regulatory Methods
Available online: https://pub.norden.org/temanord2020-507/ Abstract [en] This Nordic report builds on ideas brought forward in the OECD Detailed Review Paper (DRP) 178 on screening and testing methods and endpoints for evaluating endocrine disruptors. It was identified that the retinoid system is not presently included in any OECD test guideline, and that it is urgent to cover this knowledge gap. The present TemaNord report is a contribution to an upcoming OECD DRP on retinoids. An overview of retinoid biology in female and male reproduction is presented. The report identifies that, in general, there is a lack of studies investigating effects of chemicals on reproduction, while simultaneously examining effects on retinoid related parameters. This is a major data gap. However, selected in vitro and/or in silico retinoid-related endpoints, presented in this report, could possibly be part of a broader screening test battery aimed at reproductive toxicity.
Complex Networks & Their Applications X
This book highlights cutting-edge research in the field of network science, offering scientists, researchers, students, and practitioners a unique update on the latest advances in theory and a multitude of applications. It presents the peer-reviewed proceedings of the X International Conference on Complex Networks and their Applications (COMPLEX NETWORKS 2021). The carefully selected papers cover a wide range of theoretical topics such as network models and measures; community structure, network dynamics; diffusion, epidemics and spreading processes; resilience and control as well as all the main network applications, including social and political networks; networks in finance and economics; biological and neuroscience networks, and technological networks.
Salt Stress, Microbes, and Plant Interactions: Mechanisms and Molecular Approaches
This book offers an overview of salt stress, which has a devastating effect on the yields of various agricultural crops around the globe. Excessive salts in soil reduce the availability of water, inhibit metabolic processes, and affect nutrient composition, osmotic balance, and hydraulic conductivity. Plants have developed a number of tolerance mechanisms, such as various compatible solutes, polyamines, reactive oxygen species and antioxidant defense mechanisms, ion transport and compartmentalization of injurious ions. The exploitation of genetic variation, use of plant hormones, mineral nutrients, soil microbe interactions, and other mechanical practices are of prime importance in agriculture, and as such have been the subject of multidisciplinary research. Covering both theoretical and practical aspects, the book provides essential physiological, ecological, biochemical, environmental and molecular information as well as perspectives for future research. It is a valuable resource for students, teachers and researchers and anyone interested in agronomy, ecology, stress physiology, environmental science, crop science and molecular biology.
Techniques and Concepts of High Energy Physics X
The Proceedings of the tenth Advanced Study Institute (ASI) on Tech niques and Concepts of High Energy Physics are dedicated to Jane and Bob Wilson. Jane joined Bob at St. Croix for the first session of this Institute, after Bob had stepped down as director of Fermilab, and was scheming to build a modest charm factory in the parking lot of Columbia University's Nevis Laboratory. Through the years, Bob has been a great friend of the School, and much of its success and flavor can be attributed to his guidance and support. The 1998 meeting was held once again at the Hotel on the Cay, and, as before, the work and the fun went on very enjoyably. We had a to tal of 76 participants from 23 countrie...
Thermoplastic Aromatic Polymer Composites
Thermoplastic Aromatic Polymer Composites: A Study of the Structure, Processing and Properties of Carbon Fibre Reinforced Polyetheretherketone and Related Materials deals with the field of thermoplastic composite materials through a study of carbon fiber reinforced polyetheretherketone. The book is composed of twelve chapters. The first four chapters are an introduction and basic learning of thermoplastic composite materials. These chapters include discussions on the components of thermoplastics, product forms, and the microstructure of aromatic polymer composites. The processing and manufacturing technology, including the fundamental operations, control, and the wide implications of manufac...
Distribution Theory of Algebraic Numbers
The book timely surveys new research results and related developments in Diophantine approximation, a division of number theory which deals with the approximation of real numbers by rational numbers. The book is appended with a list of challenging open problems and a comprehensive list of references. From the contents: Field extensions • Algebraic numbers • Algebraic geometry • Height functions • The abc-conjecture • Roth's theorem • Subspace theorems • Vojta's conjectures • L-functions.
Renal Fibrosis: Mechanisms and Therapies
This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some...
Elementary Methods of Graph Ramsey Theory
This book is intended to provide graduate students and researchers in graph theory with an overview of the elementary methods of graph Ramsey theory. It is especially targeted towards graduate students in extremal graph theory, graph Ramsey theory, and related fields, as the included contents allow the text to be used in seminars. It is structured in thirteen chapters which are application-focused and largely independent, enabling readers to target specific topics and information to focus their study. The first chapter includes a true beginner’s overview of elementary examples in graph Ramsey theory mainly using combinatorial methods. The following chapters progress through topics including the probabilistic methods, algebraic construction, regularity method, but that's not all. Many related interesting topics are also included in this book, such as the disproof for a conjecture of Borsuk on geometry, intersecting hypergraphs, Turán numbers and communication channels, etc.
