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Protein NMR Techniques
When I was asked to edit the second edition of Protein NMR Techniques, my first thought was that the time was ripe for a new edition. The past several years have seen a surge in the development of novel methods that are truly revolutionizing our ability to characterize biological macromolecules in terms of speed, accuracy, and size limitations. I was particularly excited at the prospect of making these techniques accessible to all NMR labs and for the opportunity to ask the experts to divulge their hints and tips and to write, practically, about the methods. I commissioned 19 chapters with wide scope for Protein NMR Techniques, and the volume has been organized with numerous themes in mind. ...
Southeast Asian Personalities of Chinese Descent
"This is a bold project recording the lives of a particular group of Southeast Asians. Most of the people whose biographies are included here have settled down in the ten countries that constitute the region. Each of them has either self-identified as Chinese or is comfortable to be known as someone of Chinese ancestry. There are also those who were born in China or elsewhere who came here to work and do business, including seeking help from others who have ethnic Chinese connections. With the political and economic conditions of the region in a great state of flux for the past two centuries, it is impossible to find consistency in the naming process. Confucius had stressed that correct name...
The Chrysanthemum Contingency
The Chrysanthemum Contingency As the U.S. expends its major international efforts on its war against worldwide terrorism, the United States' apparent interest regarding East Asia is at an historic low ebb. Into this power vacuum come China and Japan, each quietly and relentlessly pursuing their own individual goals aimed at controlling the region. Several American foreign correspondents stationed in Tokyo become entangled in a critical revelation of secret negotiations between the two Asian powers that would, if successful, result in the exit of U.S. influence in the area and a dangerous future for all concerned, as nuclear arms and military capabilities expand for national defense purposes. A compelling story exposing current activities which may soon threaten world peace. Another reality based novel by the author of The Fugi Agenda, The Lotus And The Rose, USSA 2020, and Decay of Ivy.
Directory of Officials and Organizations in China
This exhaustive cumulative guide covers the changes in key personnel and administrative institutions from 1968 to the present. It traces the career paths of the many high officials within the numerous governmental, military, educational, and economic organizations in China. The directory also provides information on major institutions in China by following the restructuring, division, and mergers of organizations. This new edition includes new sections on trade organizations; special administrative regions; museums, libraries, and galleries; banks and insurance companies; and social and community mass organizations.
Modulating Gene Expression
RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders.
Southeast Asian Personalities of Chinese Descent: Glossary and index
This is a bold project recording the lives of a particular group of Southeast Asians. Most of the people whose biographies are included here have settled down in the ten countries that constitute the region. Each of them has either self-identified as Chinese or is comfortable to be known as someone of Chinese ancestry. There are also those who were born in China or elsewhere who came here to work and do business, including seeking help from others who have ethnic Chinese connections. With the political and economic conditions of the region in a great state of flux for the past two centuries, it is impossible to find consistency in the naming process. Confucius had stressed that correct names...
Turbulent Decade
The Great Proletarian Cultural Revolution occurred in the second decade after Mao Zedong and his comrades came to power in 1949. A comprehensive narrative account of this colossal event, written by Yan Jiaqi, one of the principal leaders of China's pro-democracy movement, and his wife, Gao Gao, a noted sociologist, appeared in Hong Kong in 1986 and was quickly banned by the Communist government. Not surprisingly, censorship and restricted circulation in China resulted in underground reproduction and serialization. The work was thus widely read, coveted, and appreciated by a populace who had just freed itself from the cultural drought and political dread of the event. Yan and Gao later spent ...
Fusion of Critical Horizons in Chinese and Western Language, Poetics, Aesthetics
This book begins with a reflection on dichotomies in comparative studies of Chinese and Western literature and aesthetics. Critiquing an oppositional paradigm, Ming Dong Gu argues that despite linguistic and cultural differences, the two traditions share much common ground in critical theory, aesthetic thought, metaphysical conception, and reasoning. Focusing on issues of language, writing, and linguistics; metaphor, metonymy, and poetics; mimesis and representation; and lyricism, expressionism, creativity, and aesthetics, Gu demonstrates that though ways of conception and modes of expression may differ, the two traditions have cultivated similar aesthetic feelings and critical ideas capable of fusing critical and aesthetic horizons. With a two-way dialogue, this book covers a broad spectrum of critical discourses and uncovers fascinating connections among a wide range of thinkers, theorists, scholars, and aestheticians, thereby making a significant contribution to bridging the aesthetic divide and envisioning world theory and global aesthetics.
Epigenetic and Genetic Mechanisms Underlying Cardiovascular Diseases and Neurodevelopmental Disorders
Cardiovascular disease (CVD) and neurodevelopmental disorders (NDD) are both common diseases seriously affecting human health. CVD refers to a broad range of disorders including diseases affecting the vasculature, the myocardium, the heart’s electrical circuit, and congenital heart disease. NDDs are conditions affecting brain development and function, mainly characterized by impairments of cognition, communication, and motor skills. Although the heart and brain develop in spatially distinct regions, they share similar genetic factors and molecular pathways which are crucial for a precise developmental trajectory. Actually, congenital CVD survivors are at a higher risk of NDD, and whole-exome sequencing revealed a significant overlap between high-risk congenital CVD and NDD genetic variants. For CVD and NDD, the clinical presentations are heterogeneous, and the etiologies are complex. Elucidating the potential pathogenic mechanisms is good for unveiling the pathophysiology and finding the novel therapeutic target.
Insights in Metabolomics: 2021
We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Metabolomics. Frontiers has organized a series of Research Topics to highlight the latest advancements in science in order to be at the forefront of science in different fields of research. This editorial initiative of particular relevance, led by Dr Wolfram Weckwerth, Specialty Chief Editor of the Metabolomics section, is focused on new insights, novel developments, current challenges, latest discoveries, recent advances and future perspectives in the field of Metabolomics.
