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This specially formulated collection features 3 reviews of current topics and key research in sweetpotato. The first chapter examines the origin and dispersal of sweetpotato, considers in vitro germplasm storage in sweetpotato genebanks, and looks at the importance of managing sweetpotato crop wild relatives (CWR). The chapter also considers the specific issues associated with sweetpotato germplasm, as well as the application of next-generation sequencing to sweetpotato and its CWR. The second chapter reviews the development and application of genetic transformation and trait improvement to sweetpotato, including the development of sweetpotato plants which are resistant to disease and abiotic stress, and sweetpotatoes with improved starch quality and higher anthocyanin content. The final chapter examines the nutritional contribution made by OFSP (orange-fleshed sweetpotato) in poor rural communities in Malawi, Ghana, Nigeria and Burkina Faso; sustainable breeding and seed systems; and effective commercialisation and marketing to benefit the communities concerned. This chapter includes detailed case studies from Ghana and Malawi.
This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
This eBook presents highlight papers from the 17th International conference of the Recycling of Agricultural, Municipal and Industrial Residues to Agriculture Network (RAMIRAN) that was held in Wexford, Ireland in September 2017. The book contains a broad range of papers around this multidisciplinary theme covering topics including regional and national organic resource use planning, impact of livestock diet on manure composition, fate and utilisation of excreta from grazing livestock, anaerobic digestion, overcoming barriers to resource reuse, hygienic aspects of residue recycling and impacts on soil health. The overarching theme being addressed is the sustainable recycling of organic residues to agriculture, to promote effective nutrient use and minimise environmental impact.
How right-wing political entrepreneurs around the world use religious offense—both given and taken—to mobilize supporters and marginalize opponents. In the United States, elements of the religious right fuel fears of an existential Islamic threat, spreading anti-Muslim rhetoric into mainstream politics. In Indonesia, Muslim absolutists urge suppression of churches and minority sects, fostering a climate of rising intolerance. In India, Narendra Modi's radical supporters instigate communal riots and academic censorship in pursuit of their Hindu nationalist vision. Outbreaks of religious intolerance are usually assumed to be visceral and spontaneous. But in Hate Spin, Cherian George shows ...
The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.