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The Pangenome
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, p...
Infectious Disease Informatics
There are several reasons to be interested in infectious disease informatics. First, it is of practical significance to understand how the technology revolution has been reshaping infectious disease research and management, as rapid advances in geno- associated technologies have changed the very nature of the questions we can ask. Second, the emerging evidence has confirmed that the application of information technologies in healthcare enhances our ability to deal with infectious diseases. Finally, the implementation of electronic health records has created new and exciting opportunities for secure, reliable and ethically sound clinical decision support and biosurveillance guided by the geno...
Reverse Vaccinology
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Pathogenomics
The first book on this young, highly dynamic, and expanding field. This comprehensive, interdisciplinary text focuses on those pathogenic bacteria that are of high scientific and public health interest, yet which also display great potential for the development of new diagnostic, prophylactic and therapeutic procedures. The authors cover all aspects of pathogenomics, including methods, genomics and applications. In addition, the ongoing development of genome, transcriptome, proteome and bioinformatic analyses of pathogenic microorganisms and their host interactions makes for a comprehensive introduction to the field of modern genomic analysis. This result is invaluable to researchers and students wishing to gain a general overview of microbial functional genome analysis and pathogenesis, while also representing a good starting point for those new to the area.
Spectacles of Waste
The modern bathroom is an ingenious compilation of locked doors, smooth porcelain, 4-ply tissue and antibacterial hand soap, but despite this miracle of indoor plumbing, we still can’t bear the thought that anyone else should know that our bodies produce waste. Why must we live by the rules of this intense scatological embarrassment? In Spectacles of Waste, leading historian of medicine Warwick Anderson reveals how human excrement has always complicated humanity’s attempts to become modern. From wastewater epidemiology and sewage snooping to fecal transplants and excremental art, he argues that our insistence on separating ourselves from our bodily waste has fundamentally shaped our philosophies, social theories, literature and art—even the emergence of high-tech science as we understand it today. Written with verve and aplomb, Anderson’s expert analysis reveals how in recent years, humanity has doubled down on abstracting and datafying our most abject waste, and unconsciously underlined its biopolitical signature across our lives.
Evolutionary Biology: Genome Evolution, Speciation, Coevolution and Origin of Life
This book includes the most essential contributions presented at the 17th Evolutionary Biology Meeting in Marseille, which took place in September 2013. It consists of 18 chapters organized according to the following categories: · Molecular and Genome Evolution · Phylogeography of Speciation and Coevolution · Exobiology and Origin of Life The aims of the annual meetings in Marseille, which bring together leading evolutionary biologists and other scientists using evolutionary biology concepts, e.g. for medical research, are to promote the exchange of ideas and to encourage interdisciplinary collaborations. Offering an overview of the latest findings in the field of evolutionary biology, this book represents an invaluable source of information for scientists, teachers and advanced students.
Neutrons and Numerical Methods - N2M
The proceedings of the Workshop on Neutrons and Numerical Methods brings together recent research which combines neutron scattering experiments and numerical modeling of interatomic forces. Since the neutron probes directly the neutron motion, a quantitative comparison of the experimental and numerical results is made. These numerical simulations give a much deeper insight into the structure and dynamics being studied. Furthermore, neutron data constitute a rigorous test of the ever-increasing number of numerical methods available, many of which are presented here. The data enable the simulation method best suited to the system under study to be selected.
Brain Fever: How Vaccines Prevent Meningitis And Other Killer Diseases
In Brain Fever, the internationally renowned medical scientist, Richard Moxon FRS, shares his experiences of bacterial meningitis, a fearful and devastating infection of the brain. In a clear, non-technical style, he explains what meningitis is, what causes it, who gets it and how research has come up with vaccines that can prevent it.A paediatrician, Moxon engages the reader in a compelling story of how chance, opportunity and passion drew him into researching the bacteria that are the dangerous assassins of unsuspecting, previously healthy people, especially young children. Moxon traces the story of his involvement as one of the extraordinary and inspiring group of scientists who pioneered...
