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Genetics of Epilepsy and Genetic Epilepsies
This volume provides updated information on epilepsy genes, on the clinical picture of genetic epilepsies discovered so far, and on conceptual advances in the complicated area of genotype-phenotype correlations. Recent studies on monogenic epilepsies present new insights into mechanisms whereby a mutation of a single gene, coding for an ion channel, can result in a complex epileptic phenotype. The analysis of genetically-determined epileptogenic dysplasia is advancing our understanding of the role of genes in controlling normal and pathological brain development. The pathogenic mechanisms by which gene mutations determine progressive myoclonus epilepsies offer critical opportunities to understand the role of genetic factors in neurodegenerative phenome-na associated with an even broader range of progressive epilepsy types. The specialists who have contributed to this book are outstanding international experts in their respective fields, ensuring first and foremost that the reviews are of relevance to clinicians dealing with epilepsy in their daily practice, as well as providing the highest quality scientific information for biomedical research.
Intelligent Decision and Policy Making Support Systems
This edited book reports recent research results and provides a state-of-the-art on intelligent decision support systems applications, lessons learned and future research directions. The book covers a balanced mixture of theory and practice, including new methods and developments of intelligent decision support systems applications in Society and Policy Support. Its main objective is to gather a peer-reviewed collection of high quality contributions in the relevant topic areas.
Neurodevelopmental Disorders: Cognitive Behavioural Phenotypes
In recent years our approach to neurodevelopmental disorders has undergone extraordinary change. This has resulted from tremendous progress in various different disciplines including developmental neuroscience, behavioural and molecular genetics, and developmental neurobiology, and from the very high quality now achievable in neuroimaging and neurophysiological techniques. This publication aims to provide a concise and interdisciplinary approach to the study of the different cognitive/behavioural phenotypes encountered in a wide range of neurodevelopmental disorders. Starting from methodological, nosographic, and assessment premises, the book deals with selected disorders of a defined but still complex genetic aetiology, and concludes with a description of the neuropsychiatric disorders that are most commonly encountered during development.
Principles and Practice of Lifespan Developmental Neuropsychology
Lifespan developmental neuropsychology is the study of the systematic behavioral, cognitive, and psychosocial changes and growth that occur across infancy, adolescence, adulthood and later life. This book provides insight into how brain-behavior relationships change over time, how disorders differ in presentation across the lifespan, and what longer-term outcomes look like. Providing practical guidance in a succinct and accessible format, this book covers the most common neurodevelopmental, behavioral and cognitive disorders, including but not limited to ADHD, cerebral palsy, traumatic brain injury, and epilepsy. Key points concerning the practice of developmental neuropsychology are emphasized in order to aid understanding of neuropsychological development and its impact on behavior, emotion, cognition, and social integration. This will be essential reading for advanced graduate students and early career professionals in the fields of neuropsychology, pediatric psychology, clinical psychology, school psychology, and rehabilitation psychology, as well as practitioners in the allied fields that interact with neuropsychology.
Neurocutaneous Syndromes in Children
Neurocutaneous Syndromes unify a group of rare neurological disorders in which the initial identification depends on simple visual disgnosis. They include a large group of neurological disorders which feature cutaneous and ocular lesions, brain malformations, central and peripheral brain tumours, mental retardation, seizures and psychiatric problems. In the last few years, our knowledge of neurocutaneous syndromes has increased substantially. The aim of this volume is to provide an updated developmental perspective on these multifaceted conditions and to review their major clinical features, in particular their embryological basis, clinical molecular genetics, diagnostic protocols and novel therapeutic approaches.
Neurobiology, Diagnosis and Treatment in Autism
Autism is an extremely complex neurodevelopmental disorder that is expressed in a spectrum of phenotypes and is characterised by impaired reciprocal social communication and stereotyped patterns of interests and activities. Its aetiopathogenesis remains poorly understood. This exhaustive synthesis discusses various aspects: A focus on the neurobiology of autism: the candidate genes implicate an involvement of numerous brain regions and a concomitant malfunctioning of neurotransmitter, immunologic, and other mechanisms; The most incisive rehabilitation models in their original formulation and the results achieved with the same or similar protocols in Italian centres (understanding, language therapy, social skill training; The psychopharmacologic options for the condition of autism per se and for its associated, very frequent, comorbidities. It suggests a potential influence on professional practice and enables an up-to-date approach to effective diagnosis and treatment.
Self-healing Materials
The book covers self-healing concepts for all important material classes and their applications: polymers, ceramics, non-metallic and metallic coatings, alloys, nanocomposites, concretes and cements, as well as ionomers. Beginning with the inspiration from biological self-healing, its mimickry and conceptual transfer into approaches for the self-repair of artificially created materials, this book explains the strategies and mechanisms for the readers' basic understanding, then covers the different material classes and suitable self-healing concepts, giving examples for their application in practical situations. As the first book in this swiftly growing research field, it is of great interest to readers from many scientific and engineering disciplines, such as physics and chemistry, civil, architectural, mechanical, electronics and aerospace engineering.
Multi-Scale and High-Contrast PDE
Contains the proceedings of the conference Multi-Scale and High-Contrast PDE: From Modelling, to Mathematical Analysis, to Inversion, held June, 2011. The volume focuses on recent progress towards a complete understanding of the direct problem with high contrast or high frequencies, and unified approaches to the inverse and imaging problems for both small and large contrast or frequencies. It also includes contributions on the inverse problem, both on its analysis and on numerical reconstructions.
