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Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.
Growth is one of the human body’s most intricate processes: each body part or region has its own unique growth patterns. Yet at the individual and population levels, growth patterns are sensitive to adverse conditions, genetic predispositions, and environmental changes. And despite the body’s capacity to compensate for these developmental setbacks, the effects may be far-reaching, even life-long. The Handbook of Growth and Growth Monitoring in Health and Disease brings this significant and complex field together in one comprehensive volume: impact of adverse variables on growth patterns; issues at different stages of prenatal development, childhood, and adolescence; aspects of catch-up g...
This book focuses on current and innovative technologies in perinatal medicine, specifically the period from the third trimester of pregnancy up to one month after birth. It follows the Second International Summer School on Technologies and Signal Processing in Perinatal Medicine (TSPPM 2021) and includes a number of the master lectures presented at the school. The book aims to provide an overview of current data processing and machine learning approaches, with clear indications and exhaustive presentations on research trends in the field, written by top scientists and researchers. It also presents the underlying clinical aspects and ethico-legal issues associated with the adoption of these technologies, particularly artificial intelligence tools. Innovative Technologies and Signal Processing in Perinatal Medicine: Volume 2 provides students, researchers, and practitioners with the knowledge necessary to carry out basic and applied research on the development of perinatal medicine medical devices with a particular emphasis on software design and development.
Diabetes: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide among diabetologists, endocrinologists, and nutritionists in understanding and treating diabetes. The book covers, in a single volume, the science of oxidative stress in diabetes and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, receptor-mediated responses and more. This approach recognizes that diseases are usually multifactorial and that oxidative stress is a single component of this.Pharmacological treatments for diabetes are commo...
This book presents the latest evidence-based guidelines for perinatal management and is designed to help obstetricians and neonatologists minimize complications and offer patients the best possible care. Since 1960, there has been a significant increase in basic and clinical investigations on normal and pathological pregnancy in the developed world. This has provided insights into the physiopathology of pregnant women, fetuses and newborns and led to the development of new technologies, bringing about a new medical subspecialty: perinatal medicine. The book is divided into eight main sections: The first examines basic periconceptional care and discusses the ethical aspects of perinatology. T...
1. Prenatal Diagnosis of Chromosomal Abnormalities Asma Khalil, Amy Coates 2. Fetal Dysmorphology Nirmala Chandrasekharan, Amarnath Bhide 3. Impact of Advances in Genetics on Prenatal Diagnosis Tessa Homfray 4. Fetal Infections Francesco D'Antonio, Amarnath Bhide 5. Fetal Growth Restriction Giorgio Pagani, Amarnath Bhide 6. Early Pregnancy Complications Parikshit Dahyalal Tank 7. Identification and Antepartum Surveillance of High Risk Pregnancy Amol P. Pawar, Kaizad R. Damania 8. Preterm Birth Lilian Alabi-Isama, Austin Ugwumadu 9. Post Term and Prolonged Pregnancy Avinash Bhatt, Kaizad R. Damania 10. Antepartum Haemorrhage Vedrana Caric, Amarnath Bhide 11. Venous Thromboembolism in Pregnanc...
Fetal growth restriction (FGR) is a condition that affects 5%–10% of all pregnancies and is the second most common cause of perinatal mortality. Fetuses with FGR present with a greater risk of long-term health defects as impaired neurological and cognitive development and cardiovascular or endocrine diseases in adulthood. Due to its high prevalence and serious long term consequences, an in-depth understating of the diagnosis and management of FGR is essential for all those professionals involved in prenatal care, since it can prevent unwanted outcomes both to the mother and to the newborn. On the last years, the knowledge about fetal growth restriction has evolved considerably, with an inc...
In Challenging Pregnancy, Genevieve Grabman recounts being pregnant with identical twins whose circulatory systems were connected in a rare condition called twin-to-twin transfusion syndrome. This is the story of Grabman's harrowing pregnancy and the science and politics of maternal healthcare in the United States, where every person must self-advocate for the desired outcome of their own pregnancy.
This beautifully illustrated book provides a practical step-by-step guide to all the laparoscopic and hysteroscopic procedures performed by gynecologists. Each procedure is described in detail and fully illustrated with color photographs. The potential complications are described, and the circumstances in which a procedure is contraindicated are ex
Covers the latest insights in fetal therapy and provides essential knowledge for maternal-fetal and neonatology specialists.