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Anticancer Agents from Natural Products, Second Edition
The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well ...
North Sea Region Climate Change Assessment
This book offers an up-to-date review of our current understanding of climate change in the North Sea and adjacent areas, as well as its impact on ecosystems and socio-economic sectors. It provides a detailed assessment of climate change based on published scientific work compiled by independent international experts from climate-related disciplines such as oceanography, atmospheric sciences, marine and terrestrial ecology, using a regional evaluation and review process similar to that of the Intergovernmental Panel on Climate Change (IPCC). It provides a comprehensive overview of all aspects of our changing climate, discussing a wide range of topics including past, current and future climate change, and climate-related changes in marine, terrestrial and freshwater ecosystems. It also explores the impact of climate change on socio-economic sectors such as fisheries, agriculture, coastal zone management, coastal protection, urban climate, recreation/tourism, offshore activities/energy, and air pollution.
Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject wi...
The Wall in My Head
On the night of November 9, 1989, after months of unrest in Europe and East Germany, the checkpoints between East and West Berlin were suddenly openedk, reuniting the two sides of the divided city and bringing together a divided Europe and led to the end of the Cold War. This collection of essays from Words Without Borders is an exciting anthology that features fiction, essays and original documents and trace the path of the revolutionary spirit from its origins to the present day.
True North
True North: Literary Translation in the Nordic Countries is the first book to focus solely on literary translation from, to, and between the Nordic tongues. The book is divided into three main sections. These are novels, children’s literature, and other genres – encompassing drama, crime fiction, sagas, cookbooks, and music – although, naturally, there are connections and overlapping themes between the sections. Halldór Laxness, Virginia Woolf, Selma Lagerlöf, Astrid Lindgren, Mark Twain, Henrik Ibsen, Henning Mankell, Janis Joplin, and Jamie Oliver are just some of the authors analysed. Topics examined include particular translatorial challenges; translating for specific audiences o...
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