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Humanity in a Creative Universe
Much of Stuart Kauffman's work in the philosophy of evolutionary biology has centered on the question of what he calls "prestatability" in evolution: that is, whether or not science can precisely predict the future development of biological features in organisms, using a singular "FinalTheory" of evolution. In this book, Kauffman argues that the development of life on earth is not prestatable, because no theory could ever fully account for the limitless variability of evolution. He believes that the biological universe's primary trait is that it is creative, and that acknowledgingthis creativity will lead to a radically different way in which humans view themselves and all other living being...
Tau oligomers
Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, t...
Plasticity in the sensory systems of invertebrates
The visual, olfactory, auditory and gustatory systems of invertebrates are often used as models to study the transduction, transmission and processing of information in nervous systems, and in recent years have also provided powerful models of neural plasticity. This Research Topic presents current views on plasticity and its mechanisms in invertebrate sensory systems at the cellular, molecular and network levels, approached from both physiological and morphological perspectives. Plasticity in sensory systems can be activity- dependent, or occur in response to changes in the environment, or to endogenous stimuli. Plastic changes have been reported in receptor neurons, but are also known in o...
Transcription Regulation - Brain Development and Homeostasis - A Finely Tuned and Orchestrated Scenario in Physiology and Pathology, Volume II
A finely tuned regulation of gene expression is essential for shaping the nervous system and for maintaining its homeostasis throughout life. Disruptions in gene regulation can impact brain development and physiology in ways that contribute to diverse pathologies. The master orchestrators of gene activity in the nucleus are transcription factors, proteins that recognize and bind to specific DNA motifs in regulatory regions and drive changes in gene expression. Transcription factors act with the help of other co-factor proteins, including components of the Mediator complex, histone modifying enzymes, chromatin modelers, and DNA methylases. In addition, transcription factor activity in the ner...
The Emerging Physics of Consciousness
Seeks answers to these questions using the underlying assumption that consciousness can be understood using the intellectual potential of modern physics and other sciences. There are a number of theories of consciousness, some based on classical physics while others require the use of quantum concepts. The latter ones have drawn criticism from the parts of the scientific establishment while simultaneously claiming that classical approaches are doomed to failure. The contributing authors presents a spectrum of opinions from both sides of this on-going scientific debate, allowing readers to decide for themselves which of the approaches are most likely to succeed.
Untangling the Role of Tau in Physiology and Pathology
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Importance Of Iron In Pathophysiologic Conditions
The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protei...
