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A large proportion of cancers is preventable. External factors, discovered by epidemiological studies during the last 50 years, account for a majority of all cancer deaths. However, still rather little is known, about how environmental and genetic factors interact, how they may regulate gene activation etc. And it is a long way from the discovery of a basic regulatory mechanism to practical patient treatment. This volume describes the present state of the art in carcinogenesis, possibilities for cancer prevention, and gives genetic background in cancer development. Attention is given to the host-environment interaction, considering how this interaction may lead to cancer formation and how it can be utilised in cancer prevention. The molecular basis for cancer development and the molecular basis for prevention are described.
The use of dietary supplements in the United States is widespread and continues to grow as more people seek alternative and complimentary medicines. Herbal products are mainly regulated as dietary supplements but our scientific understanding of the efficacy of these botanical supplements remains limited. This book provides the latest findings and perspectives related to dietary supplements, phytochemistry of botanical dietary supplements, bioactive compounds in teas and fruits, and the safety and bioactivity of selected dietary supplements.
Historical scholarship is currently undergoing a digital turn. All historians have experienced this change in one way or another, by writing on word processors, applying quantitative methods on digitalized source materials, or using internet resources and digital tools. Digital Histories showcases this emerging wave of digital history research. It presents work by historians who – on their own or through collaborations with e.g. information technology specialists – have uncovered new, empirical historical knowledge through digital and computational methods. The topics of the volume range from the medieval period to the present day, including various parts of Europe. The chapters apply an...
Ensimmäinen maininta nykyisin Pertunmaan kuntaan, aikaisemmin Mäntyharjuun kuuluneen Höltän kylän vanhimmasta tunnetusta asukkaasta, koko kylän kattaneen Höltän tilan isännästä Olli Paavonpojasta on vuodelta 1527. Sukukirjassa tarkastellaan hänen jälkipolviaan ja suvun laajenemista kantatilalta lohkotuille useille erillisille tiloille, naapurikyliin Anettuun ja Kuorttiin, laajemmallekin Pertunmaalle ja Mäntyharjuun sekä lähikuntiin kuten Heinolaan, Hartolaan ja Hirvensalmelle. Nykyisin Höltän kylän yhdeksästä suurimmasta tilasta kahdeksan on edelleen Olli Paavonpojan jälkipolvien hallussa. Isännät olivat sukunimeltään Hölttiä, kunnes vävyjä tuli isänniksi taloi...
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