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Pharmacokinetics
Pharmacologists can be considered pioneers of the study of kinetics of materials introduced into biological systems. The study of drug kinetics is particularly suited to a formulation of relatively simple models which make possible an interpretation of the time-dependent nature of various important phenomena (e. g. distribution by means of diffu sion through membranesl. The objective of the NATO ASI Course on Pharmacokinetics was that of presenting and dis cussing the mathematical and statistical approaches current ly available or being developed for the description, inter pretation and prediction of the fate of drugs and tracer substances administered to living beings. Different physi cal m...
Kinetics of Drug Action
Most drugs, toxins, hormones, and the like bring about their biologic actions by reacting with specific receptors somewhere in the body. Scientists working in all areas of biologic science have shown increasing interest in the analysis of drug-receptor interactions in the broadest sense. Studies of drugs (binding) to receptors in situ and to isolated and partly purified receptors are becoming common practice. The action of a drug in the body is, however, a kinetic event not only with respect to transport of drug molecules to the environment of the receptors, but also with respect to the drug-receptor interaction itself. Kinetics of Drug Action is an integrative approach to drug transport thr...
Daniels' Orchestral Music
Daniels’ Orchestral Music is the gold standard for all orchestral professionals—from conductors, librarians, programmers, students, administrators, and publishers, to even instructors—seeking to research and plan an orchestral program, whether for a single concert or a full season. This sixth edition, celebrating the fiftieth anniversary of the original edition, has the largest increase in entries for a new edition of Orchestral Music: 65% more works (roughly 14,050 total) and 85% more composers (2,202 total) compared to the fifth edition. Composition details are gleaned from personal inspection of scores by orchestral conductors, making it a reliable one-stop resource for repertoire. ...
Pharmacokinetics: Basics to Applications
This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.
Physico-Chemical Aspects of Drug Action
Physico-Chemical Aspects of Drug Action, Volume 7 covers topics on drug kinetics and the overall physicochemical properties of the drug in relation therewith, and the physicochemical aspects of the drug-receptor interaction, putting emphasis on receptor mechanisms and specific properties required for certain types of drugs in this respect. The book starts with some contributions dealing with various general aspects of drug kinetics followed by some contributions dealing with the relationship between certain physicochemical properties of drug molecules and their action. The text describes the pharmacokinetics and dose-concentration relationships; the time course of the biological response to ...
Transitions in Mid-Baroque Music
Featuring 102 music examples, this edited collection features contributions by leading scholars from the UK, United States, Australasia and Europe on what characterized the period. This collection focusses on the stylistic and cultural interchange that characterizes the musical period of the mid-Baroque (c.1650-1710). The idea of musical transition during this period is evident in two principal ways: geographical and chronological (the two often overlap). Chapters examine geographical transition by tracing the exchange of regional and national styles, while considering chronological evolution from the perspective of music theory, performance practice, source studies or specific repertoires. Studies range across instrumental and vocal music, both sacred and secular, and encompass some of the main European traditions prevalent at the time: Italian, German, French and English. The collection features contributions by leading scholars from the UK, the United States, Australasia and Europe. CARRIE CHURNSIDE is Associate Professor in Music at the Royal Birmingham Conservatoire (part of Birmingham City University).
Chemotherapy
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An Early Hautboy Solo Matrix
The earliest surviving hautboy solo is a Symphonia by Johann Christoph Pez from the 1690s or early 1700s. This piece survives in two versions, as a Sonata for violin and a Symphonia for hautboy, and the differences between the two enable a comparison of how Pez viewed the character and technical capabilities of each instrument. The purpose of this edition is to show how Pez’s Symphonia can be used as a template to find other works that might become hautboy solos (treble/bass) from the last third or so of the seventeenth century when the instrument came into use. Thus Pez points the way to a seventeenth-century practice that the author demonstrates in four contemporary pieces by writing out...
Scriptoria in Medieval Saxony
This book examines for the first time the scriptorium of the Augustinian Monastery of St. Pancras in Hamersleben. In the last quarter of the 12th century six wellknown manuscripts were produced there. Of the fourteen scribeartists involved, one in particular stands out as responsible for the correct text and illustrations. The bold innovations of this master scribeartist are expressed especially in the decoration programmes of a Psalter and two Gospel books. The manuscripts produced in the Hamersleben Scriptorium, as well as its notable library, were dispersed throughout the world or thought to be lost. In this book six known manuscripts are brought home, to Hamersleben. Each manuscript is minutely analysed for its codicology, palaeography, text and illuminations. The style of script as well as the style and iconography of the illustrations are discussed in relation to those from other monasteries in Saxony, in order to examine the evolvement of the regional style.
A Bibliography on Writing and Written Language
The bibliography offers information on research about writing and written language over the past 50 years. No comprehensive bibliography on this subject has been published since Sattler's (1935) handbook. With a selection of some 27,500 titles it covers the most important literature in all scientific fields relating to writing. Emphasis has been placed on the interdisciplinary organization of the bibliography, creating many points of common interest for literacy experts, educationalists, psychologists, sociologists, linguists, cultural anthropologists, and historians. The bibliography is organized in such a way as to provide the specialist as well as the researcher in neighboring disciplines with access to the relevant literature on writing in a given field. While necessarily selective, it also offers information on more specialized bibliographies. In addition, an overview of norms and standards concerning 'script and writing' will prove very useful for non-professional readers. It is, therefore, also of interest to the generally interested public as a reference work for the humanities.
