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Chromosomal Instability and Aging
This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.
Descendants of My Great-grandparents
Peter Scheibly/Shively (1742-1823), according to family tradition, was born in Switzerland, and immigrated to Pennsylvania before the Revolutionary War. He served with the Northampton County Miltia during the Revolutionary War. He married twice and was the father of eighteen children, born 1772-1805. The family moved from Berks County, Pennsylvania, to Tyrone Township, Cumberland County, now Perry County, Pennsylvania, in 1789. Descendants lived in Pennsylvania and elsewhere. Descendants spelled their surname Scheibly, Shively, Sheibley, and other variant spellings.
Learning the Language of Addiction Counseling
Comprehensive and current Learning the Language of Addiction Counseling, Third Edition introduces students to the field of addiction counseling and helps them develop the knowledge, understanding, and skills needed to counsel people who are caught in the destructive cycle of addiction. Drawing from her years of experience working in the addiction-counseling field, Geri Miller provides a balanced overview of the major theoretical underpinnings and clinical practices in the field, covering all of the essentials—from assessment and diagnosis of addiction to preparing for certification and licensure as an addiction professional. Fully revised and expanded, the Third Edition offers a positive, ...
DNA Repair in Cancer Therapy
A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.
Plague Among the Magnolias
Plague Among the Magnolias explores the social, political, racial, and economic consequences of the 1878 yellow fever epidemic in Mississippi.
Primary Immunodeficiency Diseases
The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
