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This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The rea...
This book is narrative of the author's spiritual development, told in poetry and visual art. It is a collection of visions, inner knowings, personal revelations, dream journeys and healing lessons for the mind, spirit and soul. The author explores themes like the Rastafari faith, her Taino Indigenous heritage, Buddhism, Shamanism, Voudun, Sufism, Motherhood and how they all can lead to the Warrior Path, with over 25 vividly colorful images, soul stirring poems and brief scholarly essays.
Positive laws on generators in powerful pro-p groups / C. Acciarri and G.A. Fernandez-Alcober -- Periodic groups saturated by dihedral subgroups / B. Amberg and L. Kazarin -- A note on finite groups in which the conjugacy class sizes form an arithmetic progression / M. Bianchi, A. Gillio and P.P. Palfy -- A survey of recent progress on non-abelian tensor squares of groups / R.D. Blyth, F. Fumagalli and M. Morigi -- Conjugacy classes of subgroups of finite p-groups: the first gap / R. Brandl -- The Tutte polynomial of the Schreier graphs of the Grigorchuck group and the Basilica group / T. Ceccherini-Silberstein, A. Donno and D. Iacono -- On maximal subgroups of the alternating and symmetric ...
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
The volume contains a collection of research articles by leading experts in group theory, and reports of several accessible surveys of recent research in the area. The compilation provide an overview of the diversity of themes and applications that interest today's group theorists. The topics covered in this volume include: character theory, combinatorial group theory, varieties of groups, conjugacy classes, profinite groups, graphs connected with groups, subgroup structure, representation theory.
“Drs. Butterfield, Kaufman and Marincola on behalf of the SITC have created a comprehensive must-have resource covering the basic and translational science behind approved and investigational immune therapies, and disease-by-disease clinical application of the therapies, written by leaders in the field. The textbook will be highly valuable reading for those just entering the field and for experienced scientists and clinicians looking to expand their knowledge base.” —Mario Sznol, MD, Professor of Medicine (Medical Oncology), Yale School of Medicine, New Haven, Connecticut “Given the important and exciting advances in cancer immunotherapy, it is not surprising that there is no dearth ...