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In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.
This book constitutes revised selected papers from the 17th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2021, which was held virtually during November 15–17, 2021. The 19 papers included in these proceedings were carefully reviewed and selected from 26 submissions, and they focus on bioinformatics, computational biology, health informatics, cheminformatics, biotechnology, biostatistics, and biomedical imaging.
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
The interplay between algebra and geometry is a beautiful (and fun!) area of mathematical investigation. Advances in computing and algorithms make it possible to tackle many classical problems in a down-to-earth and concrete fashion. This opens wonderful new vistas and allows us to pose, study and solve problems that were previously out of reach. Suitable for graduate students, the objective of this 2003 book is to bring advanced algebra to life with lots of examples. The first chapters provide an introduction to commutative algebra and connections to geometry. The rest of the book focuses on three active areas of contemporary algebra: Homological Algebra (the snake lemma, long exact sequence inhomology, functors and derived functors (Tor and Ext), and double complexes); Algebraic Combinatorics and Algebraic Topology (simplicial complexes and simplicial homology, Stanley-Reisner rings, upper bound theorem and polytopes); and Algebraic Geometry (points and curves in projective space, Riemann-Roch, Cech cohomology, regularity).
People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine.
"One of our most lauded scientist-writers shows how astonishing breakthroughs in medical science are changing previously immutable aspects of humanity. Welcome to a revolution in the science of human health. This book takes us to the frontier of medical research and reveals stunning recent advances that are changing our understanding of how human body works, how we combat and prevent disease and how we understand what it means to be human. We see how super-resolution nano-scopes are revealing hitherto hidden operations within our cells and opening up new new ways of manipulating the immune system; how human embryos can now be preserved alive long enough to see how genetic abnormalities can be corrected during the early stages of foetal development; how light is being used to excite pathways in the brain allowing us to understand and manipulate thoughts and feelings; how our rapidly increasing understanding of the microbiome is radically changing every aspect of human biology. These and many more astonishing discoveries are related as gripping dramas of discovery by an award-winning scientist at the very forefront of this adventure"--Publisher's description.
This book is a printed edition of the Special Issue "Non-canonical Kinases and Substrates in Cancer Progression" that was published in the scientific journal Cancers. It was edited by Francisco M. Vega, Ph.D. from the University of Seville in Spain. It brings together the latest views and original research on non-canonical protein kinases, substrates, and scaffolds.
Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
"People of the Desert and Sea is one of those books that should not have to wait a generation or two to be considered a classic. A feast for the eye as well as the mind, this ethnobotany of the Seri Indians of Sonora represents the most detailed exploration of plant use by a hunting-and-gathering people to date. . . . Scholarship in the best sense of the term—precise without being pedantic, exhaustive without exhausting its readers."—Journal of Arizona History "To read and gaze through this elegantly illustrated book is to be exposed, as if through a work of science fiction, to an astonishing and unknown cultural world."—North Dakota Quarterly