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Self Portrait in Green
'NDiaye is a hypnotic storyteller with an unflinching understanding of the rock-bottom reality of most people's life.' New York Times ' One of France's most exciting prose stylists.' The Guardian. Obsessed by her encounters with the mysterious green women, and haunted by the Garonne River, a nameless narrator seeks them out in La Roele, Paris, Marseille, and Ouagadougou. Each encounter reveals different aspects of the women; real or imagined, dead or alive, seductive or suicidal, driving the narrator deeper into her obsession, in this unsettling exploration of identity, memory and paranoia. Self Portrait in Green is the multi-prize winning, Marie NDiaye's brilliant subversion of the memoir. Written in diary entries, with lyrical prose and dreamlike imagery, we start with and return to the river, which mirrors the narrative by posing more questions than it answers.
High As the Waters Rise
This "gorgeously written" National Book Award finalist is a dazzling, heart-rending story of an oil rig worker whose closest friend goes missing, plunging him into isolation and forcing him to confront his past (NPR, One of the Best Books of the Year). One night aboard an oil drilling platform in the Atlantic, Waclaw returns to his cabin to find that his bunkmate and companion, Mátyás, has gone missing. A search of the rig confirms his fear that Mátyás has fallen into the sea. Grief-stricken, he embarks on an epic emotional and physical journey that takes him to Morocco, to Budapest and Mátyás's hometown in Hungary, to Malta, Italy, and finally to the mining town of his childhood in Ge...
Fragment-Based Drug Discovery
Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.
Killing the Water
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About Trees
About Trees considers our relationship with language, landscape, perception, and memory in the Anthropocene. The book includes texts and artwork by a stellar line up of contributors including Jorge Luis Borges, Andrea Bowers, Ursula K. Le Guin, Ada Lovelace and dozens of others. Holten was artist in residence at Buro BDP. While working on the book she created an alphabet and used it to make a new typeface called Trees. She also made a series of limited edition offset prints based on her Tree Drawings.
HIV-1 Integrase
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.
Lasso Peptides
Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into ...
The Brothers
Set among a Lebanese immigrant community in the Brazilian port of Manaus, The Brothers is the story of identical twins, Yaqub and Omar, whose mutual jealousy is offset only by their love for their mother. But it is Omar who is the object of Zana's Jocasta-like passion, while her husband, Halim, feels her slipping away from him, as their beautiful daughter, Rania, makes a tragic claim on her brothers' affection. Vivid, exotic, and lushly atmospheric, The Brothers is the story of a family's disintegration, of a changing city and the culture clash between the native-born inhabitants and a new immigrant group, and of the future the next generation will make from the ruins.
Translocator Protein (TSPO)
This book is a printed edition of the Special Issue "Translocator Protein (TSPO)" that was published in IJMS
Molecular Genetic Pathology
Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharma...
