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Extracellular and Intracellular Signaling
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
Ophthalmology Explorer
This is ophthalmology PG Exam preparation manual I have prepared during my residency and added up while preparing for senior residency/ fellowship examinations which may serve as a small guide to your exams. It will also serve as a good collection of facts which we might forget/neglect during overall MD/MS exam preparation.
Crimes of Hate
This is a collection of readings that approach hate crimes from a variety of perspectives. Part 1 provides an introduction and a comparison of both historic and modern-era hate crimes. Part 2 discuss legal developments, and some of the complexities associated with legislation and judicial interpretation. Part 3 focuses on the complex public policy issues raised in creating laws to define hate crimes, and shows how public policy development reflects both political and practical considerations. Readings in the next section examine the perpetrators, showing that these crimes relate to diverse theoretical perspectives and a wide range of methods. Part 5 examines and discusses organized hate grou...
Yes, Minister
None
Science
Science: A Four Thousand Year History rewrites science's past. Instead of focussing on difficult experiments and abstract theories, Patricia Fara shows how science has always belonged to the practical world of war, politics, and business. Rather than glorifying scientists as idealized heroes, she tells true stories about real people - men (and some women) who needed to earn their living, who made mistakes, and who trampled down their rivals in their quest for success. Fara sweeps through the centuries, from ancient Babylon right up to the latest hi-tech experiments in genetics and particle physics, illuminating the financial interests, imperial ambitions, and publishing enterprises that have...
Cardiac Resynchronization Therapy
Cardiac resynchronization therapy (CRT) is one of the most exciting new advances in the treatment of chronic severe (NYHA symptom class) heart failure associated with dyssynchronous ventricular contraction that is refractory to medical treatment. In all randomized trials CR has resulted in improved NYHA symptom class, exercise capacity and quality
Genomic Applications in Pathology
Genomic Applications in Pathology provides a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays are discussed together with issues related to reporting, including the pathologist’s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms are detailed, as well as genomic applications in ph...
Left Atrial Appendage Closure
Percutaneous left atrial appendage (LAA) closure is an emerging technology for thromboembolic prevention in patients with atrial fibrillation (AF). The first human implantation of an LAA device occurred in 2001, and since then four devices have received CE mark approval. These devices are being widely used in Europe for LAA closure in patients who are poor candidates for long-term oral anticoagulation. In the US, the WATCHMAN device (Boston Scientific) is anticipated to receive FDA approval imminently for AF patients who are warfarin-eligible. This approval is projected to significantly expand the indications for LAA closures worldwide. Thus, the volume of procedures is anticipated to escala...
Pandora's Breeches
'Had God intended Women merely as a finer sort of cattle, he would not have made them reasonable.' Writing in 1673, Bathsua Makin was one of the first women to insist that girls should receive a scientific education. Despite the efforts of Makin and her successors, women were excluded from universities until the end of the nineteenth century, yet they found other ways to participate in scientific projects. Taking a fresh look at history, Pandora's Breeches investigates how women contributed to scientific progress. As well as collaborating in home-based research, women corresponded with internationally-renowned scholars, hired tutors, published their own books and translated and simplified important texts, such as Newton's book on gravity. They played essential roles in work frequently attributed solely to their husbands, fathers or friends.
