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Immunity to Human Fungal Pathogens: Mechanisms of Host Recognition, Protection, Pathology, and Fungal Interference
Fungi are found in virtually every environment, and comprise a significant portion of the normal microflora of healthy individuals. Some species of fungi are aeroallergen sources capable of inducing sensitization and causing exacerbation of asthma and respiratory allergy. Others are transmissible between hosts and may cause no symptoms in healthy individuals. However, immune suppressed individuals may develop invasive disease marked by tissue invasion with a potential for widespread dissemination. Existing therapies for patients consist of antifungal drugs, yet these require prolonged administration with the possibility of adverse side effects, and may be rendered ineffective by the emergenc...
Immune Response and the Eye
In memory of J. Wayne Streilein, the pioneer in ocular immunology The second edition of Immune Response and the Eye' highlights recent insights into the dangerous compromise' between the immune system and the eye, which protects the eye against pathogens while limiting inflammation and immune-mediated injury to ocular tissues with little or no regenerative potential. It discusses the broad spectrum of physiological, immunological, anatomical, and biochemical adaptations that conspire to closely regulate the tone and tenor of immune responses in the eye. This volume further describes immune-mediated diseases that occur when the compromise between the immune system and the eye is breached. This breakdown in immune privilege threatens the vision of millions each year. Finally, recent advances in ocular immunology are presented, which offer potential therapeutic applications in corneal and retinal transplantation and in the management of blinding autoimmune diseases of the eye. Eye researchers, ophthalmologists and immunologists will appreciate the state-of-the-art and authoritative information presented in Immune Response and the Eye'
Wolbachia
Wolbachia are Gram-negative bacteria that form intracellular inherited infections in many invertebrates. They are extremely common, with 20-75% of all insects being infected. Moreover, they infect numerous noninsect invertebrates including nematodes, mites and spiders. Approximately 120 million people are infected by filarial nematode parasites worldwide. Transmitted to humans through mosquitoes and black flies, the majority of the disease-causing nematodes are hosts to the Wolbachia bacteria. These nematodes cause the often devastating diseases elephantiasis and onchocerciasis, commonly referred to as filariasis. Moreover, heartworm disease, caused by another Wolbachia-containing nematode, ...
The Headaches
Established worldwide as the one definitive, encyclopedic reference on headache, The Headaches is now in its thoroughly revised, updated Third Edition. The foremost international authorities examine the mechanisms of over 100 types of headache and provide evidence-based treatment recommendations, including extensive tables of controlled clinical trials. This edition presents the revised International Headache Society classification of headaches and explains how to use this new classification for accurate diagnosis. Many headache entities are discussed for the first time, such as chronic migraines; primary headache attributed to sexual activity; primary stabbing, cough, exertional, and thunderclap headaches; hypnic headaches; and new daily persistent headaches. A new section focuses on childhood headaches. Chapters that focus on headaches in elderly patients and patients with psychiatric or medical diseases are also included.
Biology of Parasitism
Biology of Parasitism is based on the Biology of Parasitism Course at the Marine Biological Laboratory in Woods Hole, Massachusetts. Having just celebrated its 20th offering, this Course has distinguished itself as the premier, world-renowned training ground for future generations of parasitologists. The primary goal of the Course is to attract and introduce the very best and most promising young researchers to the many unresolved problems in parasitology and prepare them for their future as independent investigators in the field. The rigorous program combines state-of-the-art laboratory research with a program of visiting lecturers who bring together the most current research in the field. ...
Immunology, Inflammation and Diseases of the Eye
This selection of articles from the Encyclopedia of the Eye provides a comprehensive overview of immunological features, diseases and inflammation of the eye and its support structures and organs. Rather than taking an immunological focus that is strictly suitable for clinicians, the volume offers a considerable basic science background and addresses a broad range of topics - the immune system of the eye, its various disorders, mechanisms of inflammation of the eye and visual system, treatment, wound healing mechanisms, stem cells, and more. The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of ocular immunology Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers The best researchers in the field provide their conclusions in the context of the latest experimental results
The Eye
The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today's ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome aff...
Your Dry Eye Mystery Solved
A top expert reveals his insights into Meibomian gland dysfunction, a ubiquitous, misunderstood disease that leads to Dry Eye syndrome In Reversing Dry Eye Syndrome (Yale University Press 2007), ophthalmologist Steven Maskin introduced readers to Dry Eye syndrome, explaining what the syndrome is, why it occurs, and how it can best be managed and treated. In Your Dry Eye Mystery Solved, he reveals his recent discoveries and treatments for Meibomian gland dysfunction (MGD), an underlying disease that leads to Dry Eye syndrome and involves blockage of the oil-producing tear glands within the eyelids. Not only are these glands key to clear vision and comfortable eyes, but when disrupted they can cause severe pain and a host of related symptoms.
The Role of the Fungal Cell Wall in Host-Fungal Interactions
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
David Livingstone and the Myth of African Poverty and Disease
This study about David Livingstone is different from all other publications about him. Here, Livingstone is not the main topic of interest; the focus of the author is on nutrition and health in pre-colonial Africa and Livingstone is his key informant. David Livingstone and the Myth of African Poverty and Disease is an unusual book. After a close examination of Livingstone’s writings and comparative reading of contemporary authors, Sjoerd Rijpma has been able to draw cautious conclusions about the relatively favourable conditions of health and nutrition in southern and central Africa during the pre-colonial period. His findings shed new light on the medical history of Sub-Saharan Africa. The surprise awaiting travellers in and also before 19th century Africa was that the inhabitants of the interior, even the ‘slaves’, were healthier and better fed than many of their contemporaries in Europe’s Industrial Revolution. “An impressive piece of scholarship, truly forensic in its close reading and re-reading of Livingstone’s published works and those of other travellers during the same era, clearly a labour of love which has taken years to complete” (Joanna Lewis).
