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Cytotoxicity
Compensating for cytotoxicity in the multicellular organism by a certain level of cellular proliferation is the primary aim of homeostasis. In addition, the loss of cellular proliferation control (tumorigenesis) is at least as important as cytotoxicity, however, it is a contrasting trauma. With the disruption of the delicate balance between cytotoxicity and proliferation, confrontation with cancer can inevitably occur. This book presents important information pertaining to the molecular control of the mechanisms of cytotoxicity and cellular proliferation as they relate to cancer. It is designed for students and researchers studying cytotoxicity and its control.
Lymphocytes
Although all the features of the immune system have not been fully resolved yet, the knowledge we have gained from studies on lymphocytes, the basic elements of the immune system, is quite lucid. For this reason, the significance of lymphocytes (the cells that are the source of most of the information we have obtained about the human genome, the negative effects of drugs on the genetic system, the development and behavior of immune system, antigen-antibody association, cytotoxic adaptive immunity, antibody-driven adaptive immunity, cancer and autoimmune diseases) is clear. Studies on lymphocytes will not only help us develop tools to combat human diseases more effectively in the future, but will also help us understand how evolution shapes the immune system in living organisms.
Bioenergy Research: Basic and Advanced Concepts
This volume is first part of the five-part set on bioenergy research. This volume covers current developments and both basic and advanced concepts in bioenergy production. Based on bioenergy road map, the book will also evaluate about the ratio existing between current challenges associated and practical implementation of these biofuels. The book complies up to-date progressive development in available bioenergy options and discusses opportunities and existing risks. The main objective of the book is to provide insights into the opportunities and required actions for the development of an economically viable bioenergy industry for practical replacement of fossil fuels. This book is of interest to teachers, researchers, scientists, capacity builders and policymakers. Also the book serves as additional reading material for undergraduate and graduate students of environmental sciences. National and international bioenergy scientists, policy makers will also find this to be a useful read. Other four volumes of this set explore latest developments, commercial opportunities, waste to energy and integrated solution for bioenergy concerns.
Transfusion Medicine and Scientific Developments
Transfusion Medicine and Scientific Developments focuses on unknown aspects of blood cells and transfusion practice. Blood transfusion medicine has become a sophisticated and specialized field of medicine. Some aspects will be discussed in this book. The book has been divided into three sections. The first section includes chapters describing the immunological and coagulation-assisting functions of red blood cells and methods to measure their life span. The second section discusses the role of platelets in inflammatory processes. The third section reviews functional dose of RBC transfusions and transfusion practice in various clinical settings.
Molecular Medicine
Molecular medicine is an applied science focused on human genes/transcripts, proteins, metabolites, and metabolic networks that describes molecular and cellular processes of health and disease onset and progression. Molecular medicine-based integrative identification and characterization of biomarker targets and their clinical translations is essential to explain/decipher the mechanism(s) underlying physiological pathways and pathological conditions, and acquire cell-targeted early interventional and therapeutic strategies in the context of precision medicine and public health. Principally, Molecular Medicine provides an overview of the latest headlines/developments of systems and molecular medicine, highlighting the emerging high-throughput technologies, promising potential applications, and progress in biomedical research and development strategies.
Science of Ashwagandha: Preventive and Therapeutic Potentials
Rapidly increasing aging population and environmental stressors are the two main global concerns of increasing incidence of a variety of pathologies in the modern society. The complex etiologies and pathologies cause major challenges to disease treatment. On the other hand, several herbs are known for their health-caring and disease-curing activities. Ashwagandha, a popular herb in Indian traditional home medicine, Ayurveda, has gathered increasing recognition in recent years when the chemically synthesized drugs for single target therapies showed limited success and adverse toxic effects. Ashwagandha is known as a powerful adaptogen and trusted to enhance function of the brain, reproductive system, cell-mediated immunity and increase the body's defense against disease, and possess anti-inflammatory, anticancer and anti-arthritic activities. In this book, for the first time, we provide a complete portrait on scientific understanding of the effects of Ashwagandha and its active principles for a variety of preventive and therapeutic activities.
Poisoning in the Modern World
Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: "All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy." This is often condensed to: "The dose makes the poison." So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.
Industrial Enzymes for Biofuels Production
Industrial Enzymes for Biofuels Production: Recent Updates and Future Trends focuses on resolving existing bottlenecks in enzymes mediated biomass to biofuels production processes through updating recent scientific knowledge and technology developments. The book provides low cost sustainable approaches to lower the cost of enzymes production following different approaches. It is specifically focused on industrial aspects of enzymes used in biofuels production processes by presenting in-depth study of existing issues related to practical viability and long-term sustainability. The book covers detailed discussions on market scenario of industrial enzymes used in biofuels production processes and compares them on both lab and industrial scale. Users will find this to be a great resource that also helps them develop low cost green technologies for enzyme development in biofuels production.
Medical Toxicology
Medical toxicology is a sub-branch of toxicology concerned with the diagnosis, management, and prevention of poisoning and other adverse effects of drugs, cosmetics, personal care products, occupational and environmental toxicants, and biological agents. Poisoning with drugs, herbs, venoms, and toxins is a significant global public health problem. Medical toxicologists are involved in the assessment and treatment of acute or chronic poisoning, substance abuse, adverse drug reactions, drug overdoses, envenomation, industrial accidents, and other chemical exposures. As such, there is a pressing need for safe and specific antidotes, as many antidotes currently in use have a relatively low margin of safety or therapeutic index. This book focuses on poisonings with drugs, venoms, toxins, interaction in clinics, antidotes, and forensics. It provides qualified scientific knowledge on different aspects of medical toxicology, drug and substance abuse, clinical interactions between drugs and herbs, antidotes, antidote networks, and forensic toxicology.
