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This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.
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The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
The AACR Annual Meeting highlights the best cancer science and medicine from institutions all over the world. Attendees are invited to stretch their boundaries, form collaborations, attend sessions outside their own areas of expertise, and learn how to apply exciting new concepts, tools, and techniques to their own research. Part A contains abstracts 1-3062 accepted for the 2017 meeting.
Dass die Homosexualitätsskandale 1907-09 zu einer nachhaltigen Erschütterung des wilhelminischen Kaiserreichs führten, darüber besteht in der Forschung heute ein breiter Konsens. Weitgehend unklar blieben allerdings die politischen Hintergründe jener mit den Namen des prominenten politischen Publizisten Maximilian Harden und der beiden einflussreichen Kaiserfreunde Kuno Moltke und Philipp Eulenburg verknüpften Sensationsprozesse. Sind die Prozesse, wie in der historischen Literatur vielfach angenommen, primär als der Rachefeldzug Hardens und des mit ihm verbündeten Friedrich von Holstein gegen den Fürsten Eulenburg zu verstehen, dem eine unheilvolle Beeinflussung des Kaisers in auß...
In Rereading German History, first published in 1997, Richard J. Evans draws together his seminal review essays on the political, economic, cultural and social history of Germany through war and reunification. This book provides a study of how and why historians – mainly German, American, British and French – have provided a series of differing and often conflicting readings of the German past. It also presents a reconsideration of German history in the light of the recent decline of the German Democratic Republic, collapse of the Berlin Wall and the reunification of Germany. Rereading German History re-examines major controversies in modern German history, such as the debate over Germany’s ‘special path’ to modernity in the nineteenth and twentieth centuries, and the discussions in the 1980s on the uniqueness or otherwise of Auschwitz. Evans also analyses the arguments over the nature of German national identity. The book offers trenchant and important analytical insights into the history of Germany in the last two centuries, and is ideal reading material for students of modern history and German studies.