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Neurobiology, Diagnosis and Treatment in Autism
Autism is an extremely complex neurodevelopmental disorder that is expressed in a spectrum of phenotypes and is characterised by impaired reciprocal social communication and stereotyped patterns of interests and activities. Its aetiopathogenesis remains poorly understood. This exhaustive synthesis discusses various aspects: A focus on the neurobiology of autism: the candidate genes implicate an involvement of numerous brain regions and a concomitant malfunctioning of neurotransmitter, immunologic, and other mechanisms; The most incisive rehabilitation models in their original formulation and the results achieved with the same or similar protocols in Italian centres (understanding, language therapy, social skill training; The psychopharmacologic options for the condition of autism per se and for its associated, very frequent, comorbidities. It suggests a potential influence on professional practice and enables an up-to-date approach to effective diagnosis and treatment.
Child Neuropsychology
Based on the most up-to-date research, Child Neuropsychology is a thorough and accessible guide to the key concepts and basic processes central to neuropsychological assessment and child evaluation. Essays by leading experts in the field cover basic neuropsychological functions and related disorders in the context of brain development. Divided into three parts, the text begins with clear definitions of the concepts and methodology of brain development in child neuropsychology. Part two examines normal and abnormal functional development. The final part considers professional practice and provides valuable insights into the special problems of neuropsychological assessment of infants and children in clinical and educational settings.
Neurology of the infant
In the first two years of life, several important and interlinked neurological functions develop; this is a decisive developmental period. Neurological disorders arising in early childhood therefore require special attention and should be defined precisely. To be understood and managed correctly, these disorders (epilepsy, cerebral lesions, tumours, nerve damage, etc.) must be considered as a whole. By compartmentalizing the disorders and only focusing on a certain number of them, physicians run the risk of neglecting others which could have been useful in reaching a more accurate diagnosis. Written by neuropaediatricians with the aim of sharing their knowledge, this book is the only one of its kind to date to explore, in such detail, all the factors which have the potential to perturb neurological development.
Paediatric Neurological Disorders with Cerebellar Involvement
This book provides an update on pediatric neurological disorders with cerebellar involvement. The opening section of the volume is dedicated to the structure and function of cerebellum: the specific development of the cerebellum, unlike other structures of the central nervous system, begins at a later stage of foetal development and lasts longer, even after birth, thus making the cerebellum particularly vulnerable to a wide range of insults, both genetic and acquired. Of particular interest are chapters that focus on cerebellar disorders, which may occur in isolation, or else as part of more complex malformations of the posterior fossa or in association with other supratentorial anomalies. S...
From Action to Cognition
Extensive neurophysiological and neuropsychological evidence show that perception, action, and cognition are closely related in the brain and develop in parallel to one another. Thus, perception, cognition, and social functioning are all anchored in the actions of the child. Actions reflect the motives, the problems to be solved, and the constraints and possibilities of the child's body and sensory-motor system. The developing brain accumulates experiences, which it translates into knowledge used in planning future actions. Such knowledge is available because events are governed by rules and regulations. The present volume discusses all these aspects of how action and cognition are related in development.
Emery and Rimoin's Essential Medical Genetics
For decades, Emery and Rimoin’s Principles and Practice of Medical Genetics has provided the ultimate source for practicing clinicians to learn how the study of genetics can be integrated into practice. Developed in parallel to the sixth edition, and featuring 174 original contributions from the many authors of the full set, this one volume work expertly condenses and synthesizes the most clinically relevant content, for convenient desk reference. Helping to bridge the gap between high-level molecular genetics and individual application, it follows the multi-volume set in encompassing scientific fundamentals, full spectrum discussion of major inherited disorders, and actionable therapies. ...
Gene Expression to Neurobiology and Behaviour
How does the genome, interacting with the multi-faceted environment, translate into the development by which the human brain achieves its astonishing, adaptive array of cognitive and behavioral capacities? Why and how does this process sometimes lead to neurodevelopmental disorders with a major, lifelong personal and social impact? This volume of Progress in Brain Research links findings on the structural development of the human brain, the expression of genes in behavioral and cognitive phenotypes, environmental effects on brain development, and developmental processes in perception, action, attention, cognitive control, social cognition, and language, in an attempt to answer these questions. - Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Visual Impairment in Children due to Damage to the Brain
Clinics in Developmental Medicine No.186 The increased awareness of cerebral visual impairment in children, combined with improved recognition of its wide ranging manifestations, has led to its recognition as the most common cause of visual impairment in children in the developed world. Yet the subject is in its infancy, with very little published to date. Information on this complex topic has been needed by all disciplines working with disabled children for many years. This ambitious book links the work of authors from many of the major research teams in this field, who have made significant contributions to the literature on the subject of cerebral visual impairment and provide a structured amalgam of the viewpoints of different specialists. The book contains some very novel concepts, which will be of great practical value to those who care for children with visual impairment due to brain injury. Summaries of the more specialist chapters as well as clear diagrams and a glossary have been provided to increase the book’s accessibility to a broader readership. This is an exciting and important field, to which this book makes a major contribution.
