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Unraveling
When your patients begin to die at an alarming rate, you want to know why. When one of those patients was your own wife, it becomes deeply personal. When your children and very existence are threatened, it becomes a crusade. Dr. Sean Nolan is on a search for answers. As the mystery unravels, so do human lives. While more people in the small town step forward to help him, there are others that want old secrets to remain buried. As each day passes, their desperation grows, and the efforts to stop the investigation are escalating out of control. Even murder becomes a viable option.
Virulence
Dr. Sean Nolan had never entertained the idea of becoming a part-time medical detective. His first venture had been an accidental inquiry. When the cancer deaths in his small-town practice began to rise, even claiming his own wife, he wanted to know why, and who was responsible. With no rule other than to find the truth, his unorthodox approach, occasionally stretching legal boundaries, proved an unstoppable force that left no unanswered questions. His second investigative foray is no accident. Forty-seven people are dead in California from an outbreak of Legionnaires’ disease. The Center for Disease Control has not been able to locate the source. With the outbreak fading, they have been reassigned, but the CDC director has asked Dr. Nolan to take a second look. He has been given two weeks to find the key piece of evidence. Utilizing his own unique methods, and an unlikely group of associates, the door he unlocks is not to a single mystery, but a complex web of secrets that affect thousands of lives. Unlocking the door is simple. Forcing it open is something quite different.
Unraveling
When your patients begin to die at an alarming rate, you want to know why. When one of those patients was your own wife, it becomes deeply personal. When your children and very existence are threatened, it becomes a crusade. Dr. Sean Nolan is on a search for answers. As the mystery unravels, so do human lives. While more people in the small town step forward to help him, there are others that want old secrets to remain buried. As each day passes, their desperation grows, and the efforts to stop the investigation are escalating out of control. Even murder becomes a viable option.
Primary Immunodeficiency Diseases
The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
Lymphocyte Development
"Lymphocyte Development" presents an extremely up-to-date account of molecular processes involved in the development of lymphocytes. This well written book is based on a graduate course taught by the author. Topics include the selection processes involved in lymphocyte maturation, immune receptor gene rearrangement, signaling pathways involved in cell cycle progression and apoptosis, and the transcriptional regulation of lymphoid ontogeny. The book also covers T cell development and differentiation of helper and cytotoxic T cells as well as the development of Natural Killer lymphocytes. The book finishes with an account of the molecular basis of immunodeficiency syndromes. It will interest researchers in immunology and it will be useful as a supplementary text for a graduate level immunology course.
