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The Folate Story: A vitamin under the microscope
The story of folate (vitamin B9) is one of outstanding achievements which have advanced major areas of medical practice and also of scandals of international significance.
Folate and disease prevention
This review updates the report by the Committee on Medical Aspects of Food Policy (COMA) "Folic acid and the prevention of disease" (Report on health and social subjects no. 50, 2000, ISBN 0113223048). The Committee has weighed the evidence which shows significant benefits of folic acid fortification in reducing the risk of pregnancies affected by a neural tube defect (NTD) against the evidence of potential harm in fortification in relation to delaying diagnosis of vitamin B12 deficiency and increasing the progression of bowel cancer. It recommends mandatory fortification of flour with folic acid as the most effective way to increase folate intakes of women most at risk of NTD-affected pregnancies, provided voluntary fortification is controlled and advice is given about supplement use. Such a policy is judged to be of net benefit to the UK population as it would lead to a redistribution of folic acid intakes, improving the folate intake of low consumers while reducing the intakes of high consumers.
Folic Acid and the Prevention of Disease
This COMA report reviews available evidence linking dietary folate and folic acid with human health. It is concerned particularly with the need for adequate intakes of folate at the time of conception to reduce the risk of a pregnancy being affected by neural tube defect (NTD).
Folic Acid in Neurology, Psychiatry, and Internal Medicine
Abstract: Folic acid deficiency has neurological and psychiatric, as well as nutritional, implications. In many parts of the world, folate deficiency probably is the commonest of all vitamin deficiencies. Moreover, there is increasing evidence linking it to a variety of neuropsychiatric disorders including psychiatric states and to nervous system metabolism and function. Basic and clinical studies are presented by research scientists and clinicians working on nervous system aspects of folate metabolism.
Folate in Health and Disease
During the fifteen years since the bestselling first edition of Folate in Health and Disease was published, there have been thousands of new research studies related to folate and its role in health and disease. The second edition of the book uniquely bridges the gap between basic science and public health/clinical medicine.Presents Groundbreaking
Folates and Cobalamins
The folate and cobalamin vitamins are extensively analyzed in this volume multi-authored by international experts. A variety of perspectives covers biochemical, metabolic, nutritional, and other medical aspects. The clinical aspects deal with the various consequences of a deficiency in both infants and adults; the therapeutic aspects include studies on methotrexate pharmacokinetics. The relationship between these vitamins and some pediatric, gastroenterologic, neurologic, and geriatric diseases is successively presented in this book; it serves as a complete overview to the numerous fields in which folate and cobalamin are involved.
Folic Acid Metabolism in Health and Disease
Abstract: This publication provides a background on the biochemistry and physiology of folic acid and discusses recent developments in analytical methodology and the clinical aspects of folic acid nutrition. Topics include: an historical account of the advances in the biochemistry and function of folic acid; the regulation of folic acid metabolism and the use of antagonists to study folate metabolism and transport by cells; the intestinal absorption of dietary folates; microbiological growth techniques; ani mal bioassays for measuring bioavailability of food folates; clinical aspects of dietary, physiological, and deficiency concerns; and the evaluation of folate nutritional status in infants, adolescents, adults, and other population groups.
