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The Living Age
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Type I Chaperonins: Mechanism and Beyond
Type I chaperonins are key players in maintaining the proteome of bacteria and organelles of bacterial origin. They are well known for their crucial role in mediating protein folding. For almost three decades, the molecular mechanism of chaperonin function has been the subject of intensive research. Still, surprising new mechanistic discoveries are constantly reported. It seems that we are far from having a full understanding of the chaperonin mode of action. Chaperonins are not simply protein folding machines. They also perform diverse extramitochondrial tasks, mainly related to inflammatory and signal transduction processes. This eBook constitutes ten articles highlighting the latest developments related to the divers functions of Type I chaperonins. As its title, mechanism and beyond, the collection starts with mechanistic view, continues with extracellular functions and ends with biotechnological applications of Type I chaperonins.
Mad Blood Stirring
Winner of the Howard R. Marraro Prize for Italian History from the American Historical Association Nobles were slaughtered and their castles looted or destroyed, bodies were dismembered and corpses fed to animals—the Udine carnival massacre of 1511 was the most extensive and damaging popular revolt in Renaissance Italy (and the basis for the story of Romeo and Juliet). Mad Blood Stirring is a gripping account and analysis of this event, as well as the social structures and historical conflicts preceding it and the subtle shifts in the mentality of revenge it introduced. This new reader's edition offers students and general readers an abridged version of this classic work which shifts the f...
Civil, Architecture and Environmental Engineering
This two-volume work contains the papers presented at the 2016 International Conference on Civil, Architecture and Environmental Engineering (ICCAE 2016) that was held on 4-6 November 2016 in Taipei, Taiwan. The meeting was organized by China University of Technology and Taiwan Society of Construction Engineers and brought together professors, researchers, scholars and industrial pioneers from all over the world. ICCAE 2016 is an important forum for the presentation of new research developments, exchange of ideas and experience and covers the following subject areas: Structural Science & Architecture Engineering, Building Materials & Materials Science, Construction Equipment & Mechanical Science, Environmental Science & Environmental Engineering, Computer Simulation & Computer and Electrical Engineering.
Pathways to Environmental Sustainability
This book brings together, in a single volume, an overview of multiple applications of the concept of environmental sustainability, featuring examples of useful methodologies and tools for pursuing environmental targets, experiences and case studies spanning a variety of sectors, embracing both industry and research projects; and case studies applied to very different territorial contexts. The first section of the book covers methodologies and tools for environmental sustainability, including Industrial Ecology, Urban Metabolism, Life Cycle Assessment, analysis of industrial water footprint and such chemical technologies as Hypercritical Separation Technology (HYST). Part Two provides case s...
The Venetian Discovery of America
Demonstrates how Venetian newsmongers played a crucial yet heretofore unrecognized role in the invention of America.
Mortalin Biology: Life, Stress and Death
The phrase “Life, stress and death” connects three terms, but is there a biological basis for that? Are there molecules that are essential to/or mediate these phenomena? This contributory volume “Mortalin Biology: Life, Stress and Death” is a remarkable compilation of the research outcomes on the stress protein mortalin, a member of heat shock 70 family of proteins. The book is unique as it describes mortalin playing essential role in life, stress response and death either from cancer, when it becomes hyperactive or from neuro-degeneration, when it becomes hypoactive. The book provides up-to-date knowledge on mortalin with respect to its discovery, structure, evolutionary conservatio...
Chaperones
This second edition volume expands on the previous edition with new discussions on the latest techniques used to study molecular chaperones and the stress response. The chapters in this book cover such as analysis of the initiation and regulation of the stress response; the role of heat shock protein 90 (Hsp90) in gene expression through chromosome-immunoprecipitation; features of chaperone function and biology; the emerging role of the extracellular HSPs; and the use of chaperones as biomarkers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Chaperones: Methods and Protocols, Second Edition is a valuable resource for all researchers who want to learn more about this interesting and developing field.
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