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The Chaperonopathies
This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; gen...
The Culture and Politics of Regime Change in Italy, c.1494-c.1559
This volume offers the first comprehensive survey of regime change in Italy in the period c.1494–c.1559. Far from being a purely modern phenomenon, regime change was a common feature of life in Renaissance Italy – no more so than during the Italian Wars (1494–1559). During those turbulent years, governments rose and fell with dizzying regularity. Some changes of regime were peaceful; others were more violent. But whenever a new reggimento took power, old social tensions were laid bare and new challenges emerged – any of which could easily threaten its survival. This provoked a variety of responses, both from newly established regimes and from their opponents. Constitutional reforms w...
Religion and the Senses in Early Modern Europe
This interdisciplinary volume examines the role of sensation in the religious transformations of early modern Europe. Sensation was both central to the doctrinal disputes of the Reformation and critical in shaping new or reformed devotional practices.
Cervical Spine
This heavily revised second edition covers minimally invasive and open surgical techniques for treating a variety of common and rare of cervical pathologies. Extensively revised chapters detail how to successfully perform a variety of the latest procedures for conditions including cervical spine fractures, cervical tumours and cranio cervical anomalies. Guidance on the appropriate techniques for decompression and fusion with cages and autologous bone graft are also described. Cervical Spine: Minimally Invasive and Open Surgery satisfies the need for a multi-disciplinary text covering open and minimally invasive techniques available for treating ailments of the cervical spine. Practicing and trainee orthopedic surgeons, neurosurgeons, radiologists, anesthesiologists and pain management specialists will all find the content of this work to be of a great help to them when seeking guidance on the latest advances in the field.
Immunohistochemical Expression
Immunohistochemistry (IHC) is an ancillary method, widely used in pathologists’ practice, that allows identifying diagnostic and prognostic/predictive of therapeutic response protein markers on tissue samples by the use of specific monoclonal antibodies and chromogenic substances that guarantee the visualization of an antibody–antigene binding complex under a light microscope [1]. Coon et al., in 1941 [2], first introduced the use of fluorochrome-conjugated antibodies in clinical practice. Since then, IHC has gone from being a useful tool for identifying the differentiation line of otherwise undifferentiated cells to a technique capable of providing not only diagnostic but also prognostic and predictive indications of responses to specific therapeutic options [1,3]. The abovementioned peculiarities have made IHC one of the most used ancillary methods in the histopathological approach to human neoplastic and non-neoplastic diseases [3-5]. This Special Issue contains 11 accepted papers that provide readers with a comprehensive update on current and future applications of IHC in medical practice.
Bianca Cappello
Excerpt from Bianca Cappello: A Tragedy Francesco, Prince Regent, afterwards Grand Duke of Florence and son of Cosimo de Medici. Ferdinando, Cardinal de Medici, brother of Francesco. Serguidi, minister, and confidant of the Prince Regent. Fra Fortunato, a monk, confidant of Ferdinando. Bartolomeo Cappello, a Venetian nobleman, and father of Bianca. Patriarch d'Aquilea, his brother. Roberto Ricci, a noble Florentine. Mandragoni, maestro of the ducal palace. Buonaventuri, humble citizen of Florence. Pietro, his son. Giovanni, servant of the Cardinal. Jeanne, Archduchess of Austria, wife of Francesco. Bianca Cappello, wife of Pietro. Madame Mandragoni, wife of the maestro. Costanza, wife of Buo...
Littell's Living Age
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