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Pemphigus and pemphigoid diseases: in memoriam Detlef Zillikens
Pemphigus and pemphigoid diseases are a heterogenous group of autoimmune blistering disorders (AIBD) characterized by tissue-bound and circulating autoantibodies against structural proteins of the desmosome and basement membrane zone of the skin and orifice-close mucosal tissues. While strong evidence has been provided that autoantibodies in AIBD are pathogenic, the exact mechanisms of how blister formation is mediated is very different between pemphigus and pemphigoid disorders and yet incompletely understood. Additionally, target antigens for the major AIBDs have already been identified on the molecular level. In contrast, diagnostic assays are not yet available for all autoantibody specif...
Skin Autoimmunity
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AutoImmune Blistering Disease Part I, An Issue of Dermatologic Clinics
In the first volume of this two part issue devoted to Autoimmune Blistering Diseases (AIBD), diagnosis and clinical features of these diseases are covered by an internationally recognized group of authors. Topics include Pemphigus Vulgaris, Pemphigus Foliaceus, Linear IgA Bullous Disease, and Hair and Nail Loss in AIBD.
Blistering Diseases
This book is a comprehensive compendium of current knowledge on inherited and autoimmune blistering diseases that relates advances in our understanding of the pathogenetic mechanisms to management of the individual diseases. The aim is to provide a detailed reference for dermatologists who care for patients with these conditions and a useful “one-stop information shop” for specialists outside of dermatology. The book opens by describing the structure and biology of the epidermis and basement membrane zone and discussing the genes and proteins that are targets for mutations and autoantibodies. The role of the various diagnostic tests is explained, and clinical manifestations of the specific diseases are presented with the aid of many high-quality illustrations. The forms of treatment appropriate in specific conditions are then described in depth, with coverage of dressings, drugs, surgical procedures, gene therapy, and other novel approaches. Helpful algorithms are included both for testing and monitoring and for treatment.
Autoantibodies
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Treatment of Skin Disease E-Book
Covering nearly 260 of the most common dermatologic conditions from A to Z, Treatment of Skin Disease, 6th Edition, by Drs. Mark G. Lebwohl, Warren R. Heymann, Ian Coulson, and Dedee Murrell, is your go-to resource for authoritative, evidence-based treatment strategies in your daily practice. This award-winning text provides guidance on the fast-moving dermatological therapy options for virtually any skin disease you're likely to encounter, including third-line and unusual therapies when initial options have not been successful. Summaries of each treatment strategy are accompanied by detailed discussions of treatment choices, with ratings on a consistent scale ranging from clinical studies t...
Immunopathologie
En parfaite conformité avec le programme de DFASM et les ECNi, cet ouvrage rassemble les connaissances fondamentales en immunopathologie. Il présente dans le détail la vingtaine d'items du programme relevant de cette spécialité, avec des objectifs pédagogiques clairement définis, et comporte deux parties : • une partie Connaissances divisée en 24 chapitres commençant systématiquement par un rappel des objectifs pédagogiques puis développant la thématique, étayée de points clés, de notions à retenir, de tableaux et de figures ; • une partie Pratique qui propose 12 dossiers progressifs et 46 questions isolées (QRU/QRM) corrigés et commentés, offrant un outil performant d'auto-évaluation. Cette 2e édition propose une mise à jour complète des contenus et des données. Elle s'est enrichie d'un encart Réflexe transversalité en début de chapitre et d'une rubrique Notions indispensables en fin de chapitre. Accédez à la banque d'images de cet ouvrage : l'ensemble des illustrations y sont regroupées et accessibles facilement via un moteur de recherche. Et retrouvez d'autres fonctionnalités.
Psoriasis
Ce livre fait le point sur une des plus fréquentes maladies inflammatoires chroniques : le psiorasis. L'ensemble des écoles de dermatologie française a contribué à cet ouvrage, qui reprend, après un chapitre d'historique et d'introduction, les principales formes cliniques de la maladie, le diagnostic différentiel avec des dermatoses inflammatoires chroniques pouvant miner le psiorasis. Le chapitre étiologie et physiopathologie propose des hypothèses récentes sur la génération de l'inflammation et le chapitre thérapeutique reprend l'ensemble des traitements locaux et sytématiques de la maladie.
