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Stem Cell Technologies meet Stem Cell Biology to Shine New Light into Tropical Infectious Diseases
The aim of this collection of articles is to assemble advances in stem cell-based approaches and their application to the study of parasitic diseases. Tropical parasites, including unicellular protozoan organisms and helminths, represent a major public health burden, particularly in tropical regions of the world. The study of these organisms is significantly hampered by the lack of effective in vitro/ ex vivo culture systems that mimic natural conditions and facilitate a thorough understanding of parasite development and host-parasite interactions. The advent of stem cell technology offers the opportunity to derive the right cell types to culture these parasites. Moreover, stem cell-derived organoids accurately reproduce the particular niche in which the parasites grow, develop, interact with host tissues and reproduce. In addition, particularly for helminths (i.e., multicellular parasites), the identification and characterisation of the parasite’s stem cell system, will be critical to complement our current and future understanding of fundamental biological processes, such as worm maturation, and interaction with the host immune system and microbiota.
Novel Frontiers in Helminth Genomics
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Digenetic Trematodes
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A New Global Geometry?
Scrutinizes possibilities for an equalised global order, in light of recent conflicts between the world’s major powers The “post-Cold War era is definitively over,” asserted US President Joe Biden as he launched the new National Security Strategy, warning in late 2022 that “a competition is underway between the major powers to shape what comes next.” American leadership, the document declared, would be more necessary than ever to define "the future of the international order,” insisting that the US must marshal its unparalleled economic, military, and diplomatic resources to confront its geopolitical rivals. Socialist Register 2024: A New Global Geometry? takes stock of momentous...
Is this a Culture of Trauma? An Interdisciplinary Perspective
This collection brings together case studies from the social sciences, such as clinical psychology and psychotherapy, as well as articles from the humanities that examine the aesthetics of trauma as represented in film, fiction, poetry, and the graphic novel.
My Pisces Heart
With heart, humor, and razor-sharp observation, this intimate and incisive memoir traces the journey of a Black, queer woman as she searches the world for a place of security and acceptance to call home I’ve never seen home as a permanent concept; it is an image crafted from untempered glass that threatens to shatter with lack of care. Jennifer Neal was born in the United States to a family that moved continuously for their own survival and well-being—from the Great Migration to the twenty-first century. As an adult, she has continued to travel the world as a Black queer woman, across two decades and four countries—from Japan to the US and then Australia to Germany, where she has settl...
Conference Research Topic: 16th International Symposium on Schistosomiasis
Schistosomiasis is a major health problem in many tropical areas in the world. This neglected tropical disease is endemic in 78 countries and affects over 250 million worldwide. In 2021 the World Health Organization published the document “Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021−2030”, which established as goals for schistosomiasis (i) elimination of the disease as a public health problem in 78 affected countries by 2030, and (ii) elimination of transmission in 25 endemic countries by 2030. However, to achieve these goals, it is necessary to better understand the disease and its dynamics, the parasite's immunobiolo...
Gene function in schistosomes: recent advances towards a cure
Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection. Despite extensive effort to control this NTD over the yea...
Survival: August 2023
Survival, the IISS’s bimonthly journal, challenges conventional wisdom and brings fresh, often controversial, perspectives on strategic issues of the moment. In this issue: François Heisbourg assesses that Ukraine might have to accept the de facto division of the country to secure a fast track into NATO Daniel Byman writes that state ties to terrorist groups are likely to feature in the western alliance’s long-term confrontation with Russia and in its rivalry with China Juan Pablo Medina Bickel and Irene Mia assess that global climate mitigation and the energy transition could reinforce South America’s geopolitical clout From the Survival archives, the late David P. Calleo predicted in 1999 that a successful euro would enhance the EU’s diplomatic and military capabilities, while the late James Dobbins considered in 2012 how the US could prevent a war with China Dana H. Allin and John L. Harper reflect on long-time Survival contributing editor David P. Calleo’s legacy And nine more thought-provoking pieces, as well as our regular Book Reviews and Noteworthy column. Editor: Dr Dana Allin Managing Editor: Jonathan Stevenson Associate Editor: Carolyn West
