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A large number of cardiovascular diseases are accompanied by inflammation. This volume on the molecular basis of microcirculatory disorders gives a comprehensive summary of key steps in the inflammatory cascade. Leading investigators present a state-of-the-art analysis of the molecular determinants of leukocyte-endothelial cell adhesion, mechanotransduction in endothelial and inflammatory cells, mechanisms of cell activation, microvascular apoptosis with applications to ischemia-reperfusion in the brain, the heart and in venous disease, diabetes and hypertension. The book provides the latest thinking in these important cardiovascular problems, with the most contemporary literature and a look at the increasingly complex events during inflammation. Molecular biology tools, microvascular and modern bioengineering analysis are seamlessly integrated into the analysis of clinical problems. The book helps not only newcomers to gain entry into the interesting problems associated with microvascular disorders, but lays the foundation for the design of new therapeutic interventions.
A large number of cardiovascular diseases are accompanied by inflammation. This volume on the molecular basis of microcirculatory disorders gives a comprehensive summary of key steps in the inflammatory cascade. Leading investigators present a state-of-the-art analysis of the molecular determinants of leukocyte-endothelial cell adhesion, mechanotransduction in endothelial and inflammatory cells, mechanisms of cell activation, microvascular apoptosis with applications to ischemia-reperfusion in the brain, the heart and in venous disease, diabetes and hypertension. The book provides the latest thinking in these important cardiovascular problems, with the most contemporary literature and a look at the increasingly complex events during inflammation. Molecular biology tools, microvascular and modern bioengineering analysis are seamlessly integrated into the analysis of clinical problems. The book helps not only newcomers to gain entry into the interesting problems associated with microvascular disorders, but lays the foundation for the design of new therapeutic interventions.
Bioengineering is attracting many high quality students. This invaluable book has been written for beginning students of bioengineering, and is aimed at instilling a sense of engineering in them. Engineering is invention and designing things that do not exist in nature for the benefit of humanity. Invention can be taught by making inventive thinking a conscious part of our daily life. This is the approach taken by the authors of this book. Each author discusses an ongoing project, and gives a sample of a professional publication. Students are asked to work through a sequence of assignments and write a report. Almost everybody soon realizes that more scientific knowledge is needed, and a strong motivation for the study of science is generated. The teaching of inventive thinking is a new trend in engineering education. Bioengineering is a good field with which to begin this revolution in engineering education, because it is a youthful, developing interdisciplinary field.
Ch. 1. Physical mechanisms of soft tissues rheological properties / Yoram Lanir -- ch. 2. Biomechanics of an isolated single stress fiber / Masaaki Sato and Shinji Deguchi -- ch. 3. The origin of pre-stress in biological tissues - a mechano-electrochemical model : a tribute to Professor Y.C. Fung / Leo Q. Wan, X. Edward Guo and Van C. Mow -- ch. 4. How blood flow shapes neointima / Shu Q. Liu and Y.C. Fung -- ch. 5. Illuminating a path : role of biomechanics in understanding adaptive remodeling in the microcirculation / Thomas C. Skalak -- ch. 6. Computational simulations of the buckling of oval and tapered arteries / Avione Northcutt, Parag Datir and Hai-Chao Han -- ch. 7. Role of structural and signaling molecules in cardiac mechanotransduction / Anna M. Raskin, Andrew D. McCulloch and Jeffrey H. Omens -- ch. 8. A novel hemodynamic analysis of echocardiogram / Tin-Kan Hung -- ch. 9. In vitro biomechanical studies in aging human lungs / Shervin Majd and Michael Yen -- ch. 10. Modeling the oxygen uptake in pulmonary alveolar capillaries / Cheng-Jen Chuong -- ch. 11. Two bioengineering solutions for a pulmonary circulation / John B. West
Biomechanics: Principles and Applications offers a definitive, comprehensive review of this rapidly growing field, including recent advancements made by biomedical engineers to the understanding of fundamental aspects of physiologic function in health, disease, and environmental extremes. The chapters, each by a recognized leader in the field, addr
Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Biomedical Engineering Fundamentals, the first volume of the handbook, presents material from respected scientists with diverse backgrounds in physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardiac biomechanics, the mechanics of blood vessels, cochlear mechanics, biodegradable biomaterials, soft tissue replacements, cellular biomechanics, neural engineering, electrical stimulation for paraplegia, and visual prostheses. The material is presented in a systematic manner and has been updated to reflect the latest applications and research findings.
Presents Current Principles and Applications Biomedical engineering is considered to be the most expansive of all the engineering sciences. Its function involves the direct combination of core engineering sciences as well as knowledge of nonengineering disciplines such as biology and medicine. Drawing on material from the biomechanics section of The Biomedical Engineering Handbook, Fourth Edition and utilizing the expert knowledge of respected published scientists in the application and research of biomechanics, Biomechanics: Principles and Practices discusses the latest principles and applications of biomechanics and outlines major research topics in the field. This book contains a total of...
Leukocytes play an integral role in the pathogenesis of different inflammatory disorders. Recent results indicate that leukocytes are also involved in conditions that had not formerly been associated with a cytotoxic effect by leukocytes. In 27 chapters by leading investigators, this book reviews recent research on leukocyte adhesion and microvascular kinetics. Detailed descriptions of adhesive glycoproteins expressed on the surface of leukocytes and endothelial cells are given together with summaries of the current state of leukocyte rheology, kinetics and entrapment in microvessels. Since leukocytes reach all organs, the mechanisms described in this volume may apply to a wide range of card...
Category Biomedical Engineering Subcategory Contact Editor: Stern
Bioengineering is attracting many high quality students. This invaluable book has been written for beginning students of bioengineering, and is aimed at instilling a sense of engineering in them.Engineering is invention and designing things that do not exist in nature for the benefit of humanity. Invention can be taught by making inventive thinking a conscious part of our daily life. This is the approach taken by the authors of this book. Each author discusses an ongoing project, and gives a sample of a professional publication. Students are asked to work through a sequence of assignments and write a report. Almost everybody soon realizes that more scientific knowledge is needed, and a strong motivation for the study of science is generated. The teaching of inventive thinking is a new trend in engineering education. Bioengineering is a good field with which to begin this revolution in engineering education, because it is a youthful, developing interdisciplinary field.