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Molecular Basis for Microcirculatory Disorders
A large number of cardiovascular diseases are accompanied by inflammation. This volume on the molecular basis of microcirculatory disorders gives a comprehensive summary of key steps in the inflammatory cascade. Leading investigators present a state-of-the-art analysis of the molecular determinants of leukocyte-endothelial cell adhesion, mechanotransduction in endothelial and inflammatory cells, mechanisms of cell activation, microvascular apoptosis with applications to ischemia-reperfusion in the brain, the heart and in venous disease, diabetes and hypertension. The book provides the latest thinking in these important cardiovascular problems, with the most contemporary literature and a look at the increasingly complex events during inflammation. Molecular biology tools, microvascular and modern bioengineering analysis are seamlessly integrated into the analysis of clinical problems. The book helps not only newcomers to gain entry into the interesting problems associated with microvascular disorders, but lays the foundation for the design of new therapeutic interventions.
Introduction to Bioengineering
Bioengineering is attracting many high quality students. This invaluable book has been written for beginning students of bioengineering, and is aimed at instilling a sense of engineering in them. Engineering is invention and designing things that do not exist in nature for the benefit of humanity. Invention can be taught by making inventive thinking a conscious part of our daily life. This is the approach taken by the authors of this book. Each author discusses an ongoing project, and gives a sample of a professional publication. Students are asked to work through a sequence of assignments and write a report. Almost everybody soon realizes that more scientific knowledge is needed, and a strong motivation for the study of science is generated. The teaching of inventive thinking is a new trend in engineering education. Bioengineering is a good field with which to begin this revolution in engineering education, because it is a youthful, developing interdisciplinary field.
Physiology and Pathophysiology of Leukocyte Adhesion
Leukocytes play an integral role in the pathogenesis of different inflammatory disorders. Recent results indicate that leukocytes are also involved in conditions that had not formerly been associated with a cytotoxic effect by leukocytes. In 27 chapters by leading investigators, this book reviews recent research on leukocyte adhesion and microvascular kinetics. Detailed descriptions of adhesive glycoproteins expressed on the surface of leukocytes and endothelial cells are given together with summaries of the current state of leukocyte rheology, kinetics and entrapment in microvessels. Since leukocytes reach all organs, the mechanisms described in this volume may apply to a wide range of card...
Tissue Nutrition and Viability
Recent research, especially in fields of orthopaedic surgery and rehabilita tion, point to the importance of periodic, moderate stress for maintaining normal structure and function of tissues. Moreover, growth and healing of load-bearing tissues such as bone, cartilage, and intervertebral disc are especially dependent upon stress-related stimuli. Extreme levels of stress, however, are usually detrimental to tissue integrity, and most treatment regimens today address problems related to trauma and other conditions of abnormally high stress. Therefore, the purpose of this book is to bring together experts in fields of tissue nutrition and growth in order to review previous work and examine new...
Tributes to Yuan-Cheng Fung on His 90th Birthday
Ch. 1. Physical mechanisms of soft tissues rheological properties / Yoram Lanir -- ch. 2. Biomechanics of an isolated single stress fiber / Masaaki Sato and Shinji Deguchi -- ch. 3. The origin of pre-stress in biological tissues - a mechano-electrochemical model : a tribute to Professor Y.C. Fung / Leo Q. Wan, X. Edward Guo and Van C. Mow -- ch. 4. How blood flow shapes neointima / Shu Q. Liu and Y.C. Fung -- ch. 5. Illuminating a path : role of biomechanics in understanding adaptive remodeling in the microcirculation / Thomas C. Skalak -- ch. 6. Computational simulations of the buckling of oval and tapered arteries / Avione Northcutt, Parag Datir and Hai-Chao Han -- ch. 7. Role of structural and signaling molecules in cardiac mechanotransduction / Anna M. Raskin, Andrew D. McCulloch and Jeffrey H. Omens -- ch. 8. A novel hemodynamic analysis of echocardiogram / Tin-Kan Hung -- ch. 9. In vitro biomechanical studies in aging human lungs / Shervin Majd and Michael Yen -- ch. 10. Modeling the oxygen uptake in pulmonary alveolar capillaries / Cheng-Jen Chuong -- ch. 11. Two bioengineering solutions for a pulmonary circulation / John B. West
Angiogenesis: In Vivo Systems
Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. Understanding how angiogenesis "works" and how to control it, will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis cuts across virtually every discipline. The Angiogenesis Foundation identified angiogenesis as a "common denominator" in our mo...
Shu Chien
This book consists of tributes written by friends, colleagues, teachers, students and family members of Professor Shu Chien on the occasion of his 70th birthday, which was celebrated in San Diego, California on 23 June 2001, and in Taipei, Taiwan on 12 August 2001.A collection of articles was submitted prior to and following these events. Together with the precious, memorable photographs, these articles provide a valuable summary of the life and deeds of this internationally acclaimed scientist who has made major impacts in the United States, mainland China and Taiwan OCo indeed, the whole world. In response to these excellent, moving articles, Professor Shu Chien has written a piece that encompasses his entire life, from early childhood to the present. This book constitutes a most valuable biography, full of sentiment and inspiration."
Vascular Endothelium in Health and Disease
In recent years there has been rapid progress in research on vascular endothelium. This has led to significant advances in our understanding of the structure and function of vascular endothelium in health and disease, including such aspects as the permeability of endothelium in relation to its ultrastructural correlates, theoretical basis, regulatory factors, and role in atherogenesis; the interaction between endothelium and blood cells; the endothelial release and processing of a number of important physiological agents, such as eicosanoids, hemostatic factors, and histamine; the cell biology of endothelium with respect to the cytoskeletal apparatus, cell activation, and cell locomotion; an...
Phlebology ’95
The management of diseases of the venous system has evolved rapidly over the last forty years. Much of this development occured since the creation of the Union Internationale de Phlebologie (UIP) in 1959 which has helped to bring together those involved in the management of venous diseases. The Proceedings of the XII World Congress of the UIP will reflect the diversity of disciplines involved (such as phlebologists, dermatologists, surgeons, physiologists and radiologists) as well as new methods of investigation, prevention and the latest research on the topic.
