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Metabolome Analyses:
Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.
Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis
It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.
Metabolomics
Metabolomics is a rapidly emerging field in life sciences, which aims to identify and quantify metabolites in a biological system. Analytical chemistry is combined with sophisticated informatics and statistics tools to determine and understand metabolic changes upon genetic or environmental perturbations. Together with other 'omics analyses, such as genomics and proteomics, metabolomics plays an important role in functional genomics and systems biology studies in any biological science. This book will provide the reader with summaries of the state-of-the-art of technologies and methodologies, especially in the data analysis and interpretation approaches, as well as give insights into exciting applications of metabolomics in human health studies, safety assessments, and plant and microbial research.
Biodiversity
Annotation From a September 1999 conference at St. Andrews, Scotland, 21 lectures begin with the history, diversity, and discovery of natural products. Then they examine natural products from microbes, marine organisms, and plant and end by considering biosynthesis and natural products as leads for synthesis. The specific topics include the relationship between natural products and synthetic chemistry in the discovery process, signal transduction inhibitors from microorganisms, the anti- cancer dolastatins as cyanobacterial metabolites, and the traditional use of plants in the Highlands of Scotland. Annotation c. Book News, Inc., Portland, OR (booknews.com).
Harrigan
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Cereal Crops
Cereal Crops: Genetic Resources and Breeding Techniques provides the reader practical tools for understanding relationships and challenges of successful farming; improvements to genetic modifications; and environmentally sound methods of production of bulk and quality cereals including wheat, maize, rice, barley, and millets. It explores the trait mapping, cropping systems, genome engineering, and identification of specific germplasms needed for the more effective development of biotic and abiotic stress resistant cereals within the framework of ensuring future food supplies around the world. Features: Focuses on cropping systems, genetics and genome engineering for higher crop production at...
New Research on Pharmacogenetics
The terms pharmacogenomics and pharmacogenetics tend to be used interchangeably, and a precise, consensus definition of either remains elusive. Pharmacogenetics is generally regarded as the study of genetic variation that gives rise to differing response to drugs, while pharmacogenomics is the broader application of genomic technologies to new drug discovery and further characterization of older drugs. Pharmacogenetics considers one or at most a few genes of interest, while pharmacogenomics considers the entire genome. Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in drug metabolism with a particular emphasis on improving drug safety. This new book presents leading-edge research in this dynamic field.
Studies in Natural Products Chemistry
This volume presents frontier reviews of recent developments in bioactive natural products in cutting-edge areas by eminent experts in their respective fields. It is an essential addition to this important series on Natural Products Chemistry, generally acknowledged to be the leading series on this topic. • The first seven reviews cover recent developments in the field of bioactive marine natural products. • Additional coverage includes Novel Domino reactions; medicinal plants and phytochemicals; recent developments in bioactive natural peptides; the chemistry and pharmacology of natural cyclic lipopeptides; and the biological activities of Salvia . • The text includes a comprehensive review of biologically active compounds of semi-metals such as boron, silicon, arsenic, selenium and tellurium.
