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The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.
Sex Hormones not only regulate reproductive function, but they also play a prominent role in the biology and physiology of several organs/tissues and in the pathophysiology of several diseases. During the last two decades, the information on the mechanisms of action of sex hormones, such as estrogens and androgens, has rapidly evolved from the conventional nuclear receptor dependent mechanisms to include additional non-nuclear, non-genomic and receptor-independent mechanisms. This highlights the need to update the current knowledge on sex hormones and their mode of action. Increasing evidence that exogenous/epigenetic factors can influence sex hormone production and action highlights the need to update our knowledge on the mechanisms involved. This book provides a systematic and updated overview of the male/female sex-hormones and their impact in the biology and physiology of various organs. Additionally, the book discusses their positive and negative association with the pathophysiology of various diseases (e.g. osteoporosis, cardiovascular-disease, hypogonadism, reproduction, cancer) and their therapeutic potential.
The abrupt transformation of one-party Communist regimes into political systems holding competitive elections challenges theories of democracy by evolution. Part One develops an inter-active model of how the supply of parties by political elites shapes the responses of inexperienced electors, and what this means for the institutionalisation of party systems and party identification. The model is then applied to elections since 1990 in ten Central and East European democracies that are now members of the European Union. Part Two provides a definitive and up to date text of election results and the formation and disappearance of parties in these ten countries. In addition, there is a lengthy chapter on elections in Russia.
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Continues the scope of Constitutional law of 15 EU member states (2004) with coverage of the ten member states added to the EU since that publication.
ÔLots has changed in Eastern Europe in the past quarter-century and the new edition of this major study of the region sets out these changes in directions for the better and for the worse.Õ Ð Richard Rose, University of Strathclyde, UK ÔThis Handbook offers a historically informed, systematic account of the political development in Central and Eastern Europe. Two chapters lay out a framework for comparison. 26 specialists provide analyses for 19 countries. In an appendix, each of these country chapters documents election results, government composition, the electoral system, and the constitutional framework. The concluding chapter synthesizes the major results. The Handbook is the most c...
This edited collection focuses on performance practice and analysis that engages with medical and biomedical sciences. After locating the 'biologization' of theatre at the turn of the twentieth century, it examines a range of contemporary practices that respond to understandings of the human body as revealed by biomedical science. In bringing together a variety of analytical perspectives, the book draws on scholars, scientists, artists and practices that are at the forefront of current creative, scientific and academic research. Its exploration of the dynamics and exchange between performance and medicine will stimulate a widening of the debate around key issues such as subjectivity, patient narratives, identity, embodiment, agency, medical ethics, health and illness. In focusing on an interdisciplinary understanding of performance, the book examines the potential of performance and theatre to intervene in, shape, inform and extend vital debates around biomedical knowledge and practice in the contemporary moment.
A systematic comparison of electoral systems, parties and voting in 11 new European democracies, including comparisons with established democracies such as Britain. It includes basic socio-demographic data, and information about the degree of freedom and fairness in each political system.