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Outcomes of Beta Blocker Use in Advanced Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors
Abstract: Background: In patients with cirrhosis, portal hypertension increases intestinal permeability, dysbiosis, and bacterial translocation, promoting an inflammatory state that can lead to the progression of liver disease and development of hepatocellular carcinoma (HCC). We aimed to investigate whether beta blockers (BBs), which can mediate portal hypertension, conferred survival benefits in patients treated with immune checkpoint inhibitors (ICIs). Methods: We conducted a retrospective, observational study of 578 patients with unresectable HCC treated with ICI from 2017 to 2019 at 13 institutions across three continents. BB use was defined as exposure to BBs at any time during ICI the...
Face Book
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Motorboating - ND
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Student Directory
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The Lancet
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Gazette van Gend
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