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Identification and Characterization of Inhibitory Compounds for S. Neurona
The apicomplexan parasite Sarcocystis neurona is the causative agent of debilitating neurologic disease in horses, marine mammals, and several other domestic and wild animals. A new therapy to treat infected animals is needed. To address this critical need, we developed, validated, and implemented a high-throughput screen to test repurposed FDA-approved drugs and tartrolon E (trtE), a promising anti-apicomplexan natural product. We identified 19 new inhibitory compounds of S. neurona, including trtE. The lead inhibitory compound, trtE, inhibited S. neurona parasites in vitro at nM concentrations. To investigate the mechanism of action of trtE, we examined the changes in the transcriptome of ...
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Technologies for Sidestream Nitrogen Removal
Liquid streams ("reject water" or "sidestream") generated by the dewatering of digested solids generally contain high levels of ammonia and phosphorus. These liquids can be treated in separate or sidestream processes rather than being directly returned to the mainstream treatment process. Sidestream treatment processes can reduce overall energy and chemical costs and improve treatment reliability for biological nutrient removal facilities. Sidestream treatment processes can also be used for nutrient recovery and reuse. This document is a compilation of a broad range of biological and physiochemical treatment processes specifically for nitrogen removal and recovery from municipal sidestreams and ammonia-rich industrial wastewaters. The benefits of these technologies are described along with design approaches and full-scale plant experiences. Reuse of recovered ammonia in the form of aqueous ammonia and ammonium salts for industrial and agricultural applications is also discussed. Future research needs in sidestream nitrogen removal and recovery are identified and summarized.
Wastewater Engineering
This is a thorough update of an authoritative book on wastewater treatment. This text describes the rapidly evolving field of wastewater engineering technological and regulatory changes that have occurred over the last ten years in this discipline and it includes: a new view of a wastewater as a source of energy, nutrients and potable water; more stringent discharge requirements related to nitrogen and phosphorus; enhanced understanding of the fundamental microbiology and physiology of the microorganisms responsible for the removal of nitrogen and phosphorus and other constituents; an appreciation of the importance of the separate treatment of return flows with respect to meeting more string...
Wastewater Engineering: Treatment and Resource Recovery
Wastewater Engineering: Treatment and Resource Recovery, 5/e is a thorough update of McGraw-Hill's authoritative book on wastewater treatment. No environmental engineering professional or civil or environmental engineering major should be without a copy of this book - describing the rapidly evolving field of wastewater engineering technological and regulatory changes that have occurred over the last ten years in this discipline, including: a new view of a wastewater as a source of energy, nutrients and potable water; more stringent discharge requirements related to nitrogen and phosphorus; enhanced understanding of the fundamental microbiology and physiology of the microorganisms responsible...
Wastewater Engineering
This update of a popular book for civil and environmental engineering majors describes the technological and regulatory changes that have occurred over the last ten years in the discipline.
