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Tutorials in Chemoinformatics
30 tutorials and more than 100 exercises in chemoinformatics, supported by online software and data sets Chemoinformatics is widely used in both academic and industrial chemical and biochemical research worldwide. Yet, until this unique guide, there were no books offering practical exercises in chemoinformatics methods. Tutorials in Chemoinformatics contains more than 100 exercises in 30 tutorials exploring key topics and methods in the field. It takes an applied approach to the subject with a strong emphasis on problem-solving and computational methodologies. Each tutorial is self-contained and contains exercises for students to work through using a variety of software packages. The majorit...
Mitochondrial Transplantation and Transfer
Mitochondrial Transplantation and Transfer: Biology, Methods, Applications, and Disease, a volume in the Translational and Applied Bioenergetics series, offers a detailed overview of mitochondrial transplantation across fundamental biology, disease and early therapeutics research. Here, more than twenty experts in the field discuss transplantation and transfer of healthy mitochondria and define future steps to improve new therapeutic applications across a variety of diseases. Emphasis is placed on the physiology of mitochondrial transfer, isolation processes and their applications, transfer methods, and diagnostic and treatment use across cardiovascular, metabolic, and neurological diseases,...
International Business
Revised edition of International business, 2017.
Zebrafish in Development and Disease
There are only a few vertebrate systems that can be used to model human diseases for biomedical discovery. The zebrafish model provides key advantages over existing models. Their externally developing embryos provide high-throughput non-invasive imaging, chemical screening, forward and reverse genetics, and their regeneration capacity make zebrafish a valuable system for novel discovery. Developmental studies using zebrafish has influenced discoveries in many human health-related conditions. This Research Topic covers all aspects of zebrafish studies, providing developmental mechanisms to human health conditions. The aim of the Research Topic was to foster a platform to bring all levels of zebrafish research including but not limited to development, disease, regeneration, drug screening, bioinformatics and Omics studies.
Chromatin Readers in Health and Disease
Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.In the book, more than a doz...
Natural Products and Their Synthetic Scaffolds for Chronic Diseases: A Ray of Hope
From decades, natural products have been a significant source of health remedies. The use of nature-oriented, bioactive substances in the development of new drugs and traditional medicine is still the priority of the pharmaceuticals. More than 80% to 85% of people throughout the world rely on traditional medicine (TM), as their primary form of healthcare. The easily available TM, mostly herbal products prepared from whole herbs or their extracts, have a significant economic role in many Asian, African, American, and European nations. Therefore, it has become urgent to increase the TM and its constituents' quality, safety, and effectiveness. This can only be accomplished by scientifically validating the lead compounds in TM's chemical foundation and their mode of action. Thanks to the advanced technologies and equipment’s which now has made it easy to create the scaffolds of natural products in the lab, saving a great deal of time as compared to isolating the natural product from its source.
New mechanisms and therapeutics in neurodevelopmental disorders
Neurodevelopmental disorders (NDDs) are severe, heritable conditions characterized by impaired brain development and disability in cognition, social interaction and behavior. Genetic predisposition appears to interact with environmental factors to produce the onset of the disease. In the last decade genomic analysis on NDDs advanced the knowledge of the genetic causes of these disorders: most of the genes identified were not predicted from known biology, and almost all of them engage in neurodevelopmental processes. However, the same studies revealed an unexpected outcome regarding the molecular etiology: many of the same susceptibility genes as well as molecular pathways are emerging across...
Radiation Oncology
'Radiation Oncology: MCQs for Exams' (ROME) will cover the essential aspects of radiation physics, radiobiology, and clinical radiation oncology designed to meet the needs of a large scale of examinees. Topics of this new book will be in the order of our previous "Basic Radiation Oncology" (Springer, 2010) with additional two new chapters (Pediatric tumors and Rare tumors-Benign Diseases) making a total of 15 chapters and instead of old style question and answer format,current MCQ examination pattern helpful for both oral exams and written exams is used in this comprehensive bedside recall book complementing the "Basic Radiation Oncology"1st Edition.
Venture Deals
An engaging guide to excelling in today's venture capital arena Beginning in 2005, Brad Feld and Jason Mendelson, managing directors at Foundry Group, wrote a long series of blog posts describing all the parts of a typical venture capital Term Sheet: a document which outlines key financial and other terms of a proposed investment. Since this time, they've seen the series used as the basis for a number of college courses, and have been thanked by thousands of people who have used the information to gain a better understanding of the venture capital field. Drawn from the past work Feld and Mendelson have written about in their blog and augmented with newer material, Venture Capital Financings ...
