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This reference summarizes the latest research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications of these compounds in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct anti-bacterial action and as part of the adaptive immune response. Peptide Antibiotics discusses these unique compounds and their many and exciting applications, including: the distribution and classification of diverse antimicrobial peptides throughout nature the role in host defense of mucosal surface peptide antibiotics such as defensins and cathepsins the biosynthesis of lanthionine-containing antibiotic...
Presented here are recent findings on bacteriocins: plasmid-encoded toxins produced by bacteria, which differ from traditional antibiotics in killing only bacteria that are closely related to the producing strain. Included are introductory chapters on bacteriocins, microcins (low molecular weight bacteriocins), and lantibiotics (peptide antibiotics containing lanthionine), further, contributions on pore forming bacteriocins, the mechanisms of immunity to bacteriocins, uptake and secretion, as well as evolution of bacteriocins. It is of particular interest that the lantibiotic nisin is approved for use as food preservative and another lantibiotic, epidermin, has potential as a therapeutic drug against acne.
Foods fermented with lactic acid bacteria are an important part of the human diet. Lactic acid bacteria play an essential role in the preservation of food raw materials and contribute to the nutritional, organoleptic, and health properties of food products and animal feed. The importance of lactic acid bacteria in the production of foods throughout the world has resulted in a continued scientific interest in these micro-organisms over the last two decades by academic research groups as well as by industry. This research has resulted in a number of important scientific breakthroughs and has led to new applications. The most recent of these advances is the establishment of the complete genome ...
This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas am...
Describes the structure and function of important peptides from several different organisms. An exciting development is the use of these peptides or their analogues in the treatment and prevention of infectious diseases. Considers ways in which these peptides may be used to control the insect vectors of key pathogens including the malarial parasite. Discusses the role of antimicrobial peptides in the mammalian immune system and their interaction with other components of that system.
Microbes produce an extraordinary array of defense systems. This book tells the fascinating story about the evolutionary histories of bacteriocins and the ecological roles of these biological weapons in microbial communities. The book makes compelling reading for a multi-faceted scientific audience, including those working in the fields of biodiversity and biotechnology, notably in the human and animal health domain.
Products of secondary metabolism from fermentation and cell culture are mainly pharmaceuticals, ranging from traditional antibacterials like beta-lactams, new generation compounds like dalbaheptides and lantibiotics to immunomodulators and antitumor drugs. The major fields of application of these low volume/high price products are human and veterinary medicine as well as plant protection. In this volume functionally based screening approaches and the applications of molecular genetics in the discovery and process improvement of compounds are emphasized. Along with the exploitation of new sources the growing understanding of biosynthetic processes permits the identification of the genetic backgrounds. Topics included are: Novel Receptor-Active Compounds - Microbial Lipids - Microbial Siderophores - beta-Lactam Antibiotics - Peptide Antibiotics - Lantibiotics - Glycopeptide Antibiotics (Dalbaheptides) - Aminoglycosides - Products from Basidiomycetes - Cyclosporins - Secondary Products from Plant Cells - Antitumor Agents
Proceedings of the First International Workshop on Lantibiotics, April 15-18, 1991, Physikzentrum Bad Honnef, F.R.G.
An integrated review of the most recent trends in natural products, drug discovery, and key lead candidates that are outstanding for their chemistry and biology in novel drug development.
Fermented food can be produced with inexpensive ingredients and simple techniques and makes a significant contribution to the human diet, especially in rural households and village communities worldwide. Progress in the biological and microbiological sciences involved in the manufacture of these foods has led to commercialization and heightened int